Uterine Malformations: An Update of Diagnosis, Management, and Outcomes

被引:38
作者
Bhagavath, Bala [1 ]
Greiner, Ellie [2 ]
Griffiths, Kara M. [3 ]
Winter, Tom [4 ]
Alur-Gupta, Snigdha [5 ]
Richardson, Carter [6 ]
Lindheim, Steven R. [7 ]
机构
[1] Univ Rochester, Med Ctr, Sch Med & Dent, Div Reprod Endocrine Infertil,Dept Obstet & Gynec, Rochester, NY 14642 USA
[2] Wright State Univ, Boonshoft Sch Med, 128 E Apple St,Suite 3800 CHE, Dayton, OH 45409 USA
[3] Wright State Univ, Boonshoft Sch Med, Dept Obstet & Gynecol, 128 E Apple St,Suite 3800 CHE, Dayton, OH 45409 USA
[4] Univ Utah, Dept Radiol, Salt Lake City, UT 84132 USA
[5] Univ Penn, Div Reprod Endocrinol & Infertil, Philadelphia, PA 19104 USA
[6] Ctr Coll Danville, Danville, KY USA
[7] Wright State Univ, Boonshoft Sch Med, Dept Obstet & Gynecol, Div Reprod Endocrine Infertil, 128 E Apple St,Suite 3800 CHE, Dayton, OH 45409 USA
关键词
MULLERIAN DUCT ANOMALIES; KUSTER-HAUSER-SYNDROME; IN-VITRO FERTILIZATION; FOOT-GENITAL SYNDROME; SEPTATE UTERUS; 3-DIMENSIONAL ULTRASOUND; HYSTEROSCOPIC METROPLASTY; REPRODUCTIVE-PERFORMANCE; DIFFERENTIAL-DIAGNOSIS; POLYALANINE EXPANSION;
D O I
10.1097/OGX.0000000000000444
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Importance: The prevalence of uterine malformations has been reported in up to 7% of the general population and 18% of those with recurrent pregnancy loss. The diagnosis, classification, management, and outcome of the management have been subject to debate for decades. Objective: The aim of this article is to summarize the current knowledge regarding the genetics of mullerian anomalies, the varied classification schemes, the appropriate diagnostic modalities, the surgical methods, and the obstetric outcomes related to these surgical methods. Evidence Acquisition: An extensive literature review using the key words uterine anomaly, classification, mullerian, agenesis, unicornuate, didelphys, bicornuate, septate, arcuate, DES, and diethyl stilbestrol was conducted using PubMed. Only English-language publications were reviewed. Relevant references within these publications were also obtained and reviewed in preparing this article. Results: Only 4 genes have been clearly linked to mullerian anomalies in humans. All these have been described only in syndromic patients. Four different classification schemes have been proposed including the American Society of Reproductive Medicine classification. There is accumulating evidence that 3-dimensional ultrasonography is an effective and less expensive diagnostic tool. Many innovative surgical methods have been developed for the various categories of anomalies, particularly for mullerian agenesis. Although there is accumulating evidence for the improved obstetric outcomes after surgical repairs, robust evidence from randomized trials is lacking. Conclusions: Current evidence favors continued use of the American Society of Reproductive Medicine classification. Three-dimensional sonography, especially when combined with saline infusion, can be very helpful in accurately classifying mullerian anomalies. Relevance: Mullerian anomalies are relatively common. Accurate knowledge of the advantages and limitations of various diagnostic modalities, the limitations of the classification systems, the surgical options available where appropriate, and the obstetric outcomes after these surgeries will help in the optimal management of these patients. Target Audience: Obstetrician and gynecologists. Learning Objectives: After completion of this educational activity, the obstetrician/gynecologist should be better able to discuss the current controversies and new classifications of mullerian anomalies, describe the prevalence and pathogenesis of each mullerian anomaly, illustrate the various modalities for the diagnosis of mullerian anomalies, and outline the appropriate counseling and clinical practice for surgical management and obstetric outcomes for each anomaly.
引用
收藏
页码:377 / 392
页数:16
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