Rho family GTPases: more than simple switches

被引：198
作者：
Symons, M
Settleman, J
机构：
[1] Picower Inst Med Res, Manhasset, NY 11030 USA
[2] Harvard Univ, Sch Med, MGH Canc Ctr, Charlestown, MA 02129 USA
来源：
TRENDS IN CELL BIOLOGY | 2000年 / 10卷 / 10期
关键词：
D O I：
10.1016/S0962-8924(00)01832-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Rho family GTPases control a large variety of biological processes. Cycling of Rho proteins between the GDP-bound and the GTP-bound state is controlled by several classes of regulatory proteins. In this review, we discuss the signal-transduction mechanisms that control these regulators. We will emphasize the subcellular localization of Rho GTPases and their regulator), proteins and the role of GTP hydrolysis in signal transmission.
引用
收藏
页码：415 / 419
页数：5
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