Inhibitory effects of an orexin-2 receptor antagonist on orexin A- and stress-induced ACTH responses in conscious rats

被引：57
作者：
Chang, Hyukki
Saito, Tsuyoshi
Ohiwa, Nao
Tateoka, Masaru
Deocaris, Custer C.
Fujikawa, Takahiko
Soya, Hideaki
机构：
[1] Univ Tsukuba, Grad Sch Comprehens Human Sci, Lab Exercise Biochem, Tsukuba, Ibaraki 3058574, Japan
[2] Mie Univ, Grad Sch Med, Inst Genom & Regenerat Biol, Dept Biochem & Proteom, Tsu, Mie 5148507, Japan
来源：
NEUROSCIENCE RESEARCH | 2007年 / 57卷 / 03期
关键词：
orexin (hypocretin); orexin-2 receptor antagonist (OX2-RA); stress; plasma ACTH; i.c.v;
D O I：
10.1016/j.neures.2006.11.009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Orexins, recognized for their diverse functions in sleep/wakefulness/arousal and appetite regulation, may play provocative roles in stress response. Although the PVN of the hypothalamus expresses an abundance of orexin-2 receptor (OX-2R), the involvement of OX-2R in regulating ACTH response to stress remains unclear. To address this, we examined effects of a selective antagonist to OX-2R (N-{(1S)-1-[6,7-dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl}-2,2-dimethylpropyl)-N-{4-pyridinylmethyl}amine upon plasma ACTH concentrations after administration of orexin A and swimming stress. Increases in ACTH levels with orexin A or swimming stress were attenuated with prior administration of an OX-2R antagonist. These results suggest that swimming stress facilitates ACTH release, at least in part via activation of OX-2R. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
引用
收藏
页码：462 / 466
页数：5
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