Impact of gender on renal disease: the role of the renin angiotensin system

被引：0
作者：
Kang, AK
Miller, JA
机构：
[1] St Josephs Hosp, Div Nephrol, Toronto, ON, Canada
[2] Univ Toronto, Dept Med, Univ Hlth Network, Div Nephrol, Toronto, ON, Canada
来源：
CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE | 2003年 / 26卷 / 01期
关键词：
angiotensin II; estrogens; hypertension; kidney diseases; nitric oxide; renin-angiotensin system; sex characteristics;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Recent studies have identified key gender differences with respect to cardiovascular function, renal hemodynamics and the renin angiotensin system (RAS). Extensive epidemiologic evidence has shown a clear gender difference associated with progression of cardiovascular and renal disease, whereby female sex appears to be protective. The mechanisms underlying this phenomenon are unknown but likely reflect the aforementioned sex differences in common pathophysiological pathways. This review focuses on studies examining sex differences in renal function, blood pressure and the RAS, which together may provide a plausible mechanism for the gender disparity in clinical outcomes.
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收藏
页码：38 / 44
页数：7
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