mRNA and protein expression of PUMA in sporadic colorectal cancer

被引：15

作者：

Jansson, A ^{[1
]}

Arbman, G

Sun, XF

机构：

[1] Linkoping Univ, Dept Biomed & Surg, Div Oncol, S-58185 Linkoping, Sweden

[2] Vrinnevi Hosp, Dept Surg, Norrkoping, Sweden

来源：

ONCOLOGY REPORTS | 2004年 / 12卷 / 06期

关键词：

PUMA; colorectal cancer; real-time PCR; immunohistochemistry;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PUMA is a BH3-only member of the Bcl-2 family, upregulated by p53 as a response to DNA damage. We have investigated the mRNA expression of PUMA with real-time PCR in 94 colorectal adenocarcinomas and the corresponding normal mucosa. Among them PUMA protein expression was investigated with immunohistochemistry in 23 tumours and 17 corresponding normal mucosa samples. The mRNA expression of PUMA decreased in 4% and increased in 4% of the tumours compared with the normal mucosa. The protein expression of PUMA decreased in 6% and increased in 29% of the tumours compared with the normal mucosa. Decreased PUMA expression in the tumour compared with the corresponding mucosa was correlated with the distal colon and rectum (P = 0.02). We did not find any other relationship to clinical or pathological features. We suggest that the changes in PUMA expression may be of minor importance in the development of colorectal cancer.

引用

页码：1245 / 1249

页数：5

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