Venous thromboembolism in hematopoietic stem cell transplant recipients

被引：24

作者：

Chaturvedi, S. ^{[1
,2
]}

Neff, A. ^{[3
]}

Nagler, A. ^{[4
]}

Savani, U. ^{[5
]}

Mohty, M. ^{[6
]}

Savani, B. N. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Hematol & Stem Cell Transplantat Sect,Div Hematol, 1301 Med Ctr Dr,3927 TVC, Nashville, TN 37232 USA

[2] Vet Affairs Med Ctr, 1301 Med Ctr Dr,3927 TVC, Nashville, TN 37232 USA

[3] Cleveland Clin, Dept Hematol Oncol & Blood Disorders, Benign Hematol Program, Cleveland, OH 44106 USA

[4] Chaim Sheba Med Ctr, Dept Med, Div Hematol, Tel Hahomer, Israel

[5] Univ Michigan, Ann Arbor, MI 48109 USA

[6] St Antoine Hosp, Dept Haematol, Paris, France

来源：

BONE MARROW TRANSPLANTATION | 2016年 / 51卷 / 04期

关键词：

BONE-MARROW-TRANSPLANTATION; CLINICAL-PRACTICE GUIDELINES; CATHETER-RELATED THROMBOSIS; DEEP-VEIN THROMBOSIS; UNSUSPECTED PULMONARY EMBOLI; REFRACTORY MULTIPLE-MYELOMA; HUMAN ENDOTHELIAL-CELLS; LOW-DOSE DEXAMETHASONE; ILL MEDICAL PATIENTS; VERSUS-HOST-DISEASE;

D O I：

10.1038/bmt.2015.308

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Venous thromboembolism (VTE) is an increasingly recognized problem in the post-hematopoietic stem cell transplantation (HSCT) setting, with a lack of high-quality evidence-based data to recommend best practices. Few patients with hematologic malignancies and even fewer post-HSCT patients were included in randomized trials of VTE prophylaxis and treatment. Prior VTE, GVHD, infections and indwelling venous catheters are risk factors for thrombosis. The increasing use of post-transplant maintenance therapy with lenalidomide in patients with multiple myeloma adds to this risk after autologous HSCT. These patients are also at high risk of bleeding complications because of prolonged thrombocytopenia and managing the competing risks of bleeding and thrombosis can be challenging. This review aims to provide a practical, clinician-focused approach to the prevention and treatment of VTE in the post-HSCT setting.

引用

页码：473 / 478

页数：6

共 80 条

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