Leonurosides A-D: Steroid N-acetylglucosaminides from the fruits of Leonurus japonicus

被引:6
作者
Ye, Miao [1 ,2 ,3 ,4 ]
Ma, Guang-Lei [1 ]
Su, Jing-Jing [3 ,4 ]
Xiong, Juan [1 ]
Hu, Jin-Feng [1 ,3 ,4 ]
机构
[1] Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201203, Peoples R China
[2] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350122, Fujian, Peoples R China
[3] East China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China
[4] East China Normal Univ, Inst Adv Interdisciplinary Res, Shanghai 200062, Peoples R China
关键词
Leonurus japonicus; Lamiaceae; Steroid N-acetylglucosaminides; Leonurosides; DEFENSE SECRETION; BILE-ACIDS; IDENTIFICATION; PAVONININS; GLYCOSIDES; URINE;
D O I
10.1016/j.phytol.2014.10.016
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Four new naturally occurring steroidal glycosides (leonurosides A-D, 1-4) were isolated from the dried fruits of Leonurus japonicus (motherwort fruit). Their structures were established by spectroscopic and chemical methods. The monosaccharide unit was identified to be a 2-acetamido-2-deoxy-beta-D-glucose and the aglycone is either a common 3 beta-stigmasterol or 3 beta-ergosterol derivative. These compounds are the first representatives of steroid N-acetylglucosaminides from vascular plants. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:287 / 290
页数:4
相关论文
共 19 条
[1]   New phytoconstituents from the stem bark of Tinospora cordifolia Miers [J].
Ahmad, Faheem ;
Ali, Mohd. ;
Alam, Prawez .
NATURAL PRODUCT RESEARCH, 2010, 24 (10) :926-934
[2]  
Armarego W.L.F., 2003, PURIFICATION LAB CHE, P251, DOI Oxford
[3]  
Grover P, 2009, J INDIAN CHEM SOC, V86, P1112
[4]   ERYLOSIDE-E FROM AN ATLANTIC SPONGE ERYLUS-GOFFRILLERI [J].
GULAVITA, NK ;
WRIGHT, AE ;
KELLYBORGES, M ;
LONGLEY, RE ;
YARWOOD, D ;
SILLS, MA .
TETRAHEDRON LETTERS, 1994, 35 (25) :4299-4302
[5]   Lipoxygenase inhibition by anadanthoflavone, a new flavonoid from the aerial parts of Anadenanthera colubrina [J].
Gutierrez-Lugo, MT ;
Deschamps, JD ;
Holman, TR ;
Suarez, E ;
Timmermann, BN .
PLANTA MEDICA, 2004, 70 (03) :263-265
[6]   Complete 1H and 13C resonance assignments of glycosidic conjugates of non-amidated and amidated bile acids [J].
Iida, T ;
Kasuga, Y ;
Arakawa, M ;
Mushiake, K ;
Ikegawa, S ;
Goto, J ;
Nambara, T .
MAGNETIC RESONANCE IN CHEMISTRY, 2001, 39 (12) :749-756
[7]   Structure and biological evaluation of novel cytotoxic sterol glycosides from the marine red alga Peyssonnelia sp. [J].
Lin, An-Shen ;
Engel, Sebastian ;
Smith, Benjamin A. ;
Fairchild, Craig R. ;
Aalbersberg, William ;
Hay, Mark E. ;
Kubanek, Julia .
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (23) :8264-8269
[8]  
MARSCHALL HU, 1989, J BIOL CHEM, V264, P12989
[9]   Profiles of bile acids and progesterone metabolites in the urine and serum of women with intrahepatic cholestasis of pregnancy [J].
Meng, LJ ;
Reyes, H ;
Palma, J ;
Hernandez, I ;
Ribalta, J ;
Sjovall, J .
JOURNAL OF HEPATOLOGY, 1997, 27 (02) :346-357
[10]   The identification of novel steroid N-acetylglucosaminides in the urine of pregnant women [J].
Meng, LJ ;
Griffiths, WJ ;
Sjovall, J .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1996, 58 (5-6) :585-598