Estrogen-dependent induction of cyclooxygenase-2 in the canine prostate in vivo

被引：12

作者：

Doré, M ^{[1
]}

Chevalier, S ^{[1
]}

Sirois, J ^{[1
]}

机构：

[1] Univ Montreal, Fac Med Vet, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 7C6, Canada

来源：

VETERINARY PATHOLOGY | 2005年 / 42卷 / 01期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

cyclooxygenase-2; dogs; estrogen; metaplasia; prostate;

D O I：

10.1354/vp.42-1-100

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Cyclooxygenase (COX)-2 is involved in several physiologic and pathologic processes. COX-2 is overexpressed in human and canine prostate cancer, but little is known about COX-2 inducers in the prostate. Our objective was to investigate the effect of sex steroid hormones on COX-2 expression in the canine prostate in vivo. COX-2 expression was evaluated by immunohistochemistry in intact and castrated dogs treated with exogenous androgen or estrogen. Results showed that no COX-2 staining was observed in prostates of untreated or androgen-treated castrated or intact dogs. However, treatment of intact and castrated dogs with estrogen resulted in squamous metaplasia with intense COX-2 expression observed in both squamous epithelial cells and in cells of acini without metaplasia. This is the first report to demonstrate the induction of COX-2 by estrogen in the prostate in vivo.

引用

页码：100 / 103

页数：4

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