Acute Liver Failure From Sickle Cell Hepatopathy Treated With Exchange Transfusion

被引：1

作者：

Kassem, Ahmad N. ^{[1
]}

Park, Changsu ^{[1
]}

Rajkumar, Aarthi ^{[1
]}

机构：

[1] Metrohlth Med Ctr, Internal Med, Cleveland, OH 44109 USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2021年 / 13卷 / 05期

关键词：

sickle cell crisis; acute liver failure; sickle cell hepatopathy; red blood cell exchange; exchange transfusion; DISEASE;

D O I：

10.7759/cureus.15334

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sickle cell disease (SCD) is a qualitative hemoglobinopathy that can cause widespread sickling and vaso occlusive events in all organ systems. Sickle cell hepatopathy is an umbrella term for various acute and chronic pathologies of the liver as a result of sickling in SCD patients. We present below the case of a 49 year-old woman who had an acute liver failure in the setting of a hepatic crisis with recovery after exchange transfusion. Hepatic involvement in SCD may be life-threatening. Understanding the etiology and severity of hepatic involvement by sickling is necessary for appropriate treatment.

引用

页数：4

共 11 条

[1] THE LIVER IN SICKLE-CELL DISEASE - A CLINICOPATHOLOGIC STUDY OF 70 PATIENTS [J].

BAUER, TW ;

MOORE, GW ;

HUTCHINS, GM .

AMERICAN JOURNAL OF MEDICINE, 1980, 69 (06) :833-837

[2] Hepatic dysfunction in sickle cell disease: A new system of classification based on global assessment [J].

Berry, Philip A. ;

Cross, Timothy J. S. ;

Thein, Swee Lay ;

Portmann, Bernard C. ;

Wendon, Julia A. ;

Karani, John B. ;

Heneghan, Michael A. ;

Bomford, Adrian .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2007, 5 (12) :1469-1476

[3] Extracellular fluid tonicity impacts sickle red blood cell deformability and adhesion [J].

Carden, Marcus A. ;

Fay, Meredith E. ;

Lu, Xinran ;

Mannino, Robert G. ;

Sakurai, Yumiko ;

Ciciliano, Jordan C. ;

Hansen, Caroline E. ;

Chonat, Satheesh ;

Joiner, Clinton H. ;

Wood, David K. ;

Lam, Wilbur A. .

BLOOD, 2017, 130 (24) :2654-2663

[4] How we treat sickle hepatopathy and liver transplantation in adults [J].

Gardner, Kate ;

Suddle, Abid ;

Kane, Pauline ;

O'Grady, John ;

Heaton, Nigel ;

Bomford, Adrian ;

Thein, Swee Lay .

BLOOD, 2014, 123 (15) :2302-2307

[5]

Konstantinos M, 2019, GASTROENTEROL MED RE, V3

[6] Sickle Cell Disease in the Emergency Department [J].

Lovett, Paris B. ;

Sule, Harsh P. ;

Lopez, Bernard L. .

EMERGENCY MEDICINE CLINICS OF NORTH AMERICA, 2014, 32 (03) :629-+

[7] Interventions for treating intrahepatic cholestasis in people with sickle cell disease [J].

Marti-Carvajal, Arturo J. ;

Elena Marti-Amarista, Cristina .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2017, (07)

[8]

Quinn R., 2017, P UCLA HEALTHCARE, V21, P3

[9]

Shah Rushikesh, 2017, World J Gastrointest Pathophysiol, V8, P108, DOI 10.4291/wjgp.v8.i3.108

[10] Acute liver failure [J].

Stravitz, R. Todd ;

Lee, William M. .

LANCET, 2019, 394 (10201) :869-881

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