Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis

被引：114

作者：

Collin, Simon M. ^{[1
]}

Metcalfe, Chris

Refsum, Helga ^{[2
,4
]}

Lewis, Sarah J.

Zuccolo, Luisa

Smith, George Davey ^{[1
]}

Chen, Lina

Harris, Ross ^{[5
]}

Davis, Michael

Marsden, Gemma ^{[3
]}

Johnston, Carole ^{[2
]}

Lane, J. Athene

Ebbing, Marta ^{[6
]}

Bonaa, Kaare Harald ^{[8
]}

Nygard, Ottar ^{[6
,7
]}

Ueland, Per Magne ^{[6
,7
]}

Grau, Maria V. ^{[9
,10
]}

Baron, John A. ^{[9
,10
]}

Donovan, Jenny L.

Neal, David E. ^{[11
]}

Hamdy, Freddie C. ^{[3
]}

Smith, A. David ^{[2
]}

Martin, Richard M. ^{[1
]}

机构：

[1] Univ Bristol, Dept Social Med, MRC, Ctr Causal Anal Translat Epidemiol, Bristol BS8 2PS, Avon, England

[2] Univ Oxford, John Radcliffe Hosp, Dept Physiol Anat & Genet, Oxford OX3 9DU, England

[3] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England

[4] Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Oslo, Norway

[5] Hlth Protect Agcy, London, England

[6] Haukeland Hosp, Dept Heart Dis, N-5021 Bergen, Norway

[7] Univ Bergen, Inst Med, Bergen, Norway

[8] Univ Hosp N Norway, Dept Heart Dis, Tromso, Norway

[9] Dartmouth Med Sch, Dept Med, Lebanon, NH 03766 USA

[10] Dartmouth Med Sch, Dept Community & Family Med, Lebanon, NH 03766 USA

[11] Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB2 2QQ, England

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2010年 / 19卷 / 06期

关键词：

ONE-CARBON METABOLISM; FOLIC-ACID; MICROBIOLOGICAL ASSAY; METHIONINE SYNTHASE; DNA HYPOMETHYLATION; PLASMA; SERUM; TRANSCOBALAMIN; ASSOCIATION; DEFICIENCY;

D O I：

10.1158/1055-9965.EPI-10-0180

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Disturbed folate metabolism is associated with an increased risk of some cancers. Our objective was to determine whether blood levels of folate, vitamin B-12, and related metabolites were associated with prostate cancer risk. Methods: Matched case-control study nested within the U. K. population-based Prostate testing for cancer and Treatment (ProtecT) study of prostate-specific antigen-detected prostate cancer in men ages 50 to 69 years. Plasma concentrations of folate, B-12 (cobalamin), holo-haptocorrin, holo-transcobalamin total transcobalamin, and total homocysteine (tHcy) were measured in 1,461 cases and 1,507 controls. ProtecT study estimates for associations of folate, B-12, and tHcy with prostate cancer risk were included in a meta-analysis, based on a systematic review. Results: In the ProtecT study, increased B-12 and holo-haptocorrin concentrations showed positive associations with prostate cancer risk [highest versus lowest quartile of B-12 odds ratio (OR) = 1.17 (95% confidence interval, 0.95-1.43); P-trend = 0.06; highest versus lowest quartile of holo-haptocorrin OR = 1.27 (1.04-1.56); P-trend = 0.01]; folate, holo-transcobalamin, and tHcy were not associated with prostate cancer risk. In the meta-analysis, circulating B-12 levels were associated with an increased prostate cancer risk [pooled OR = 1.10 (1.01-1.19) per 100 pmol/L increase in B-12; P = 0.002]; the pooled OR for the association of folate with prostate cancer was positive [OR = 1.11 (0.96-1.28) per 10 nmol/L; P = 0.2) and conventionally statistically significant if ProtecT (the only case-control study) was excluded [OR = 1.18 (1.00-1.40) per 10 nmol/L; P = 0.02]. Conclusion: Vitamin B-12 and (in cohort studies) folate were associated with increased prostate cancer risk. Impact: Given current controversies over mandatory fortification, further research is needed to determine whether these are causal associations. Cancer Epidemiol Biomarkers Prev; 19(6); 1632-42. (C) 2010 AACR.

引用

页码：1632 / 1642

页数：11

共 53 条

[1] Reduced vitamin B12 binding by transcobalamin II increases the risk of neural tube defects [J].