Adiponectin Signaling Pathways in Liver Diseases

被引：78
作者：
Gamberi, Tania [1 ]
Magherini, Francesca [1 ]
Modesti, Alessandra [1 ]
Fiaschi, Tania [1 ]
机构：
[1] Univ Firenze, Dipartimento Sci Biomed Sperimentali & Clin Mario, Viale Morgagni 50, I-50134 Florence, Italy
来源：
BIOMEDICINES | 2018年 / 6卷 / 02期
关键词：
adiponectin; liver; signaling pathway; VISCERAL ADIPOSE-TISSUE; NECROSIS-FACTOR-ALPHA; FATTY LIVER; GLOBULAR ADIPONECTIN; NONALCOHOLIC STEATOHEPATITIS; PLASMA ADIPONECTIN; INSULIN-RESISTANCE; HEPATIC STEATOSIS; T-CADHERIN; TNF-ALPHA;
D O I：
10.3390/biomedicines6020052
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-sensitizing effect. The binding of adiponectin with its specific receptors induces the activation of a proper signaling cascade that becomes altered in liver pathologies. This review describes the different signaling pathways in healthy and diseased hepatocytes, also highlighting the beneficial role of adiponectin in autophagy activation and hepatic regeneration.
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页数：16
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