Synthesis and Fungicidal Activity of 2-Substituted-3-(4-Fluorophenyl)-benzofuro [3,2-d] Pyrimidin-4(3H)-ones

被引：4

作者：

Hu, Yang-Gen ^{[1
]}

Xu, Jing

Gao, Hai-Tao

Ma, Zuan

机构：

[1] Yunyang Med Coll, Taihe Hosp, Dept Pharm, Shiyan 442000, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2010年 / 47卷 / 01期

关键词：

D O I：

10.1002/jhet.277

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Carbodiimide, obtained from aza-Wittig reaction of iminophosphorane with 4-fluorophenyl isocyanate, reacted with various nucleophiles under mild conditions to give a series of 2-substituted-3-(4-fluorophenyl)-benzofuro [3,2-d] pyrimidin-4(3H)-ones in satisfactory yield. Their structures were confirmed using NMR, EI-Ms, IR, and elementary analysis, and compound 7b was further analyzed by single-crystal. The preliminary bioassays indicated that these compounds showed moderate fungicidal activities against six kinds of fungi at a concentration of 50 mg/L.

引用

页码：219 / 223

页数：5

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