Alterations of natural killer cells in traumatic brain injury

被引：23

作者：

Kong, Xiao-Dong ^{[1
,2
,3
]}

Bai, Sheng ^{[1
,2
]}

Chen, Xin ^{[1
,2
]}

Wei, Hui-Jie ^{[1
,2
]}

Jin, Wei-Na ^{[1
,2
]}

Li, Min-Shu ^{[1
,2
]}

Yan, Yaping ^{[1
,2
]}

Shi, Fu-Dong ^{[1
,2
,4
]}

机构：

[1] Tianjin Med Univ, Gen Hosp, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin Neurol Inst,Minist Educ,Dept Neurol, Tianjin 300052, Peoples R China

[2] Tianjin Med Univ, Gen Hosp, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin Neurol Inst,Minist Educ,Dept Neurosurg, Tianjin 300052, Peoples R China

[3] Tianjin Med Univ, Gen Hosp, Dept Geriatr, Tianjin Geriatr Inst, Tianjin 300052, Peoples R China

[4] St Josephs Hosp, Dept Neurol, Barrow Neurol Inst, Phoenix, AZ USA

来源：

NEUROSCIENCE BULLETIN | 2014年 / 30卷 / 06期

基金：

中国国家自然科学基金;

关键词：

natural killer cells; traumatic brain injury; central nervous system; immunity; ANEURYSMAL SUBARACHNOID HEMORRHAGE; HEAD-INJURY; SYSTEM; CYTOTOXICITY; RECEPTORS; PROLACTIN; CORTISOL; FEATURES; MODERATE;

D O I：

10.1007/s12264-014-1481-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the relationship between natural killer (NK) cells and traumatic brain injury (TBI), we tracked an established phenotype of circulating NK cells at several time points in patients with different grades of TBI. In serial peripheral blood samples, NK cells were prospectively measured by flow cytometry of CD3(-) CD56(+) lymphocytes. Compared to healthy controls, TBI patients had reductions in both the percentage and the absolute number of NK cells. Furthermore, the magnitude of NK cell reduction correlated with the degree of TBI severity at several time points. That is, NK cell population size was independently associated with lower Glasgow Coma Scale scores. In addition, at some time points, a positive correlation was found between the NK cell counts and Glasgow Outcome Scale scores. Our results indicate that TBI induces a reduction in the number of NK cells, and the magnitude of the reduction appears to parallel the severity of TBI.

引用

页码：903 / 912

页数：10

共 41 条

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