The medial olivocochlear reflex strength is modulated during a visual working memory task

被引:9
作者
Marcenaro, Bruno [1 ,4 ,5 ]
Leiva, Alexis [1 ,3 ]
Dragicevic, Constantino [1 ,3 ]
Lopez, Vladimir [6 ]
Delano, Paul H. [1 ,2 ,3 ,4 ]
机构
[1] Univ Chile, Fac Med, Neurosci Dept, Santiago, Chile
[2] Univ Chile, Hosp Clin, Otolaryngol Dept, Santiago, Chile
[3] Univ Chile, Fac Med, Biomed Neurosci Inst, BNI, Santiago, Chile
[4] Univ Tecn Federico Santa Maria, Ctr Avanzado Ingn Elect & Elect, AC3E, Valparaiso, Chile
[5] Pontificia Univ Catolica Chile, Escuela Psicol, Interdisciplinary Ctr Neurosci, Santiago, Chile
[6] Pontificia Univ Catolica Chile, Escuela Psicol, Santiago, Chile
关键词
auditory efferent; cochlea; corticofugal; olivocochlear; working memory; SELECTIVE ATTENTION; COCHLEAR SENSITIVITY; OTOACOUSTIC EMISSION; EVOKED-POTENTIALS; LOAD; EAR; DISTRACTORS; DISTORTION; PERIPHERY; CAPACITY;
D O I
10.1152/jn.00032.2020
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Top-down modulation of sensory responses to distracting stimuli by selective attention has been proposed as an important mechanism by which our brain can maintain relevant information during working memory tasks. Previous works in visual working memory (VWM) have reported modulation of neural responses to distracting sounds at different levels of the central auditory pathways. Whether these modulations occur also at the level of the auditory receptor is unknown. Here, we hypothesize that cochlear responses to irrelevant auditory stimuli can be modulated by the medial olivocochlear system during VWM. Twenty-one subjects (13 males, mean age 25.3 yr) with normal hearing performed a visual change detection task with different VWM load conditions (high load = 4 visual objects; low load = 2 visual objects). Auditory stimuli were presented as distractors and allowed the measurement of distortion product otoacoustic emissions (DPOAEs) and scalp auditory evoked potentials. In addition, the medial olivocochlear reflex strength was evaluated by adding contralateral acoustic stimulation. We found larger contralateral acoustic suppression of DPOAEs during the visual working memory period (n = 21) compared with control experiments (n = 10), in which individuals were passively exposed to the same experimental conditions. These results show that during the visual working memory period there is a modulation of the medial olivocochlear reflex strength, suggesting a possible common mechanism for top-down filtering of auditory responses during cognitive processes. NEW & NOTEWORTHY The auditory efferent system has been proposed to function as a biological filter of cochlear responses during selective attention. Here, we recorded electroencephalographic activity and otoacoustic emissions in response to auditory distractors during a visual working memory task in humans. We found that the olivocochlear efferent activity is modulated during the visual working memory period suggesting a common mechanism for suppressing cochlear responses during selective attention and working memory.
引用
收藏
页码:2309 / 2321
页数:13
相关论文
共 61 条
[1]   The Corticofugal Effects of Auditory Cortex Microstimulation on Auditory Nerve and Superior Olivary Complex Responses Are Mediated via Alpha-9 Nicotinic Receptor Subunit [J].
Aedo, Cristian ;
Terreros, Gonzalo ;
Leon, Alex ;
Delano, Paul H. .
PLOS ONE, 2016, 11 (05)
[2]   Executive and Perceptual Distraction in Visual Working Memory [J].
Allen, Richard J. ;
Baddeley, Alan D. ;
Hitch, Graham J. .
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN PERCEPTION AND PERFORMANCE, 2017, 43 (09) :1677-1693
[3]   WORKING MEMORY [J].
BADDELEY, AD .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1983, 302 (1110) :311-324
[4]   Maturation of the long-latency auditory ERP: step function changes at start and end of adolescence [J].
Bishop, Dorothy V. M. ;
Hardiman, Mervyn ;
Uwer, Ruth ;
von Suchodoletz, Waldemar .
DEVELOPMENTAL SCIENCE, 2007, 10 (05) :565-575
[5]   The olivocochlear reflex strength in awake chinchillas is relevant for behavioural performance during visual selective attention with auditory distractors [J].
Bowen, Macarena ;
Terreros, Gonzalo ;
Moreno-Gomez, Felipe N. ;
Ipinza, Macarena ;
Vicencio, Sergio ;
Robles, Luis ;
Delano, Paul H. .
SCIENTIFIC REPORTS, 2020, 10 (01)
[6]  
Cowan, 2016, WORKING MEMORY CAPAC
[8]   A review of the evidence for P2 being an independent component process: age, sleep and modality [J].
Crowley, KE ;
Colrain, IM .
CLINICAL NEUROPHYSIOLOGY, 2004, 115 (04) :732-744
[9]   Medial olivocochlear reflex interneurons are located in the posteroventral cochlear nucleus: A kainic acid lesion study in guinea pigs [J].
De Venecia, RK ;
Liberman, MC ;
Guinan, JJ ;
Brown, MC .
JOURNAL OF COMPARATIVE NEUROLOGY, 2005, 487 (04) :345-360
[10]   Stimulus-dependent oscillations and evoked potentials in chinchilla auditory cortex [J].
Delano, Paul H. ;
Pavez, Elizabeth ;
Robles, Luis ;
Maldonado, Pedro E. .
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 2008, 194 (08) :693-700