Chemokines and chemokine receptors: new insights into cancer-related inflammation

被引:551
作者
Lazennec, Gwendal [1 ]
Richmond, Ann [2 ,3 ]
机构
[1] Univ Montpellier 1, U844, INSERM, F-34090 Montpellier, France
[2] Vanderbilt Univ, Sch Med, Vet Affairs Med Ctr, Nashville, TN 37212 USA
[3] Vanderbilt Univ, Sch Med, Dept Canc Biol, Nashville, TN 37212 USA
关键词
MESENCHYMAL STEM-CELLS; BREAST-CANCER; TUMOR-GROWTH; BONE-MARROW; TGF-BETA; COLORECTAL-CANCER; IN-VIVO; PROMOTE METASTASIS; PROGENITOR CELLS; PROSTATE-CANCER;
D O I
10.1016/j.molmed.2010.01.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chemokines are involved in cellular interactions and tropism in situations frequently associated with inflammation. Recently, the importance of chemokines and chemokine receptors in inflammation associated with carcinogenesis has been highlighted. Increasing evidence suggests that chemokines are produced by tumor cells as well as by cells of the tumor microenvironment including cancer-associated fibroblasts (CAFs), mesenchymal stem cells (MSCs), endothelial cells, tumor-associated macrophages (TAMs) and more recently tumor-associated neutrophils (TANs). In addition to affecting tumor cell proliferation, angiogenesis and metastasis, chemokines also seem to modulate senescence and cell survival. Here, we review recent progress on the roles of chemokines and chemokine receptors in cancer-related inflammation, and discuss the mechanisms underlying chemokine action in cancer that might facilitate the development of novel therapies in the future.
引用
收藏
页码:133 / 144
页数:12
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