Simulation of pore formation in lipid bilayers by mechanical stress and electric fields

被引：378
作者：
Tieleman, DP
Leontiadou, H
Mark, AE
Marrink, SJ
机构：
[1] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada
[2] Univ Groningen, Dept Biophys Chem, NL-9747 AG Groningen, Netherlands
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 21期
关键词：
D O I：
10.1021/ja029504i
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe computer simulations of pore formation and membrane rupture of phospholipid bilayers under mechanical and electrical stress. On the nanosecond simulation time scale, pores are induced by a lateral pressure exceeding -200 bar or by an applied electric field of 0.5 V/nm. Copyright © 2003 American Chemical Society.
引用
收藏
页码：6382 / 6383
页数：2
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