Multirate delivery of multiple therapeutic agents from metal-organic frameworks

被引：50

作者：

McKinlay, Alistair C. ^{[1
]}

Allan, Phoebe K. ^{[1
]}

Renouf, Catherine L. ^{[1
]}

Duncan, Morven J. ^{[1
]}

Wheatley, Paul S. ^{[1
]}

Warrender, Stewart J. ^{[1
]}

Dawson, Daniel ^{[1
]}

Ashbrook, Sharon E. ^{[1
]}

Gil, Barbara ^{[2
]}

Marszalek, Bartosz ^{[2
]}

Dueren, Tina ^{[3
]}

Williams, Jennifer J. ^{[3
]}

Charrier, Cedric ^{[4
]}

Mercer, Derry K. ^{[4
]}

Teat, Simon J. ^{[5
]}

Morris, Russell E. ^{[1
]}

机构：

[1] Univ St Andrews, EaStCHEM Sch Chem, St Andrews KY16 9ST, Fife, Scotland

[2] Jagiellonian Univ, Fac Chem, PL-30060 Krakow, Poland

[3] Univ Edinburgh, Inst Mat & Proc, Sch Engn, Edinburgh EH9 3JL, Midlothian, Scotland

[4] NovaBiot Ltd, Aberdeen AB21 9TR, Scotland

[5] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Adv Light Source, Berkeley, CA 94720 USA

来源：

APL MATERIALS | 2014年 / 2卷 / 12期

基金：

英国工程与自然科学研究理事会;

关键词：

CARBON-DIOXIDE; ADSORPTION; STORAGE; HYDROGEN; NO;

D O I：

10.1063/1.4903290

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents-a biologically active gas, an antibiotic drug molecule, and an active metal ion-simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria. (C) 2014 Author(s).

引用

页数：8

共 31 条

[1] Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide [J].

Allan, Phoebe K. ;

Wheatley, Paul S. ;

Aldous, David ;

Mohideen, M. Infas ;

Tang, Chiu ;

Hriljac, Joseph A. ;

Megson, Ian L. ;

Chapman, Karena W. ;

De Weireld, Guy ;

Vaesen, Sebastian ;

Morris, Russell E. .

DALTON TRANSACTIONS, 2012, 41 (14) :4060-4066

[2] Hydrocarbon Separations in a Metal-Organic Framework with Open Iron(II) Coordination Sites [J].

Bloch, Eric D. ;

Queen, Wendy L. ;

Krishna, Rajamani ;

Zadrozny, Joseph M. ;

Brown, Craig M. ;

Long, Jeffrey R. .

SCIENCE, 2012, 335 (6076) :1606-1610

[3] Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America [J].

Boucher, Helen W. ;

Talbot, George H. ;

Bradley, John S. ;

Edwards, John E., Jr. ;

Gilbert, David ;

Rice, Louis B. ;

Scheld, Michael ;

Spellberg, Brad ;

Bartlett, John .

CLINICAL INFECTIOUS DISEASES, 2009, 48 (01) :1-12

[4] Highly efficient separation of carbon dioxide by a metal-organic framework replete with open metal sites [J].

Britt, David ;

Furukawa, Hiroyasu ;

Wang, Bo ;

Glover, T. Grant ;

Yaghi, Omar M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (49) :20637-20640

[5] A chemically functionalizable nanoporous material [Cu3(TMA)2(H2O)3]n [J].

Chui, SSY ;

Lo, SMF ;

Charmant, JPH ;

Orpen, AG ;

Williams, ID .

SCIENCE, 1999, 283 (5405) :1148-1150

[6]

Clinical and Laboratory Standards Institute, 2012, M07A9 CLIN LAB STAND

[7] Nanoscale Metal-Organic Frameworks for Biomedical Imaging and Drug Delivery [J].

Della Rocca, Joseph ;

Liu, Demin ;

Lin, Wenbin .

ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :957-968

[8] Base-induced formation of two magnesium metal-organic framework compounds with a bifunctional tetratopic ligand [J].

Dietzel, Pascal D. C. ;

Blom, Richard ;

Fjellvag, Helmer .

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2008, (23) :3624-3632

[9] An in situ high-temperature single-crystal investigation of a dehydrated metal-organic framework compound and field-induced magnetization of one-dimensional metaloxygen chains [J].

Dietzel, PDC ;

Morita, Y ;

Blom, R ;

Fjellvåg, H .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (39) :6354-6358

[10]

Duncan M. J., CYTOTOXICITY M UNPUB

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