Strontium and strontium ranelate: Historical review of some of their functions

被引：188
作者：
Pilmane, M. [1 ]
Salma-Ancane, K. [2 ]
Loca, D. [2 ]
Locs, J. [2 ]
Berzina-Cimdina, L. [2 ]
机构：
[1] Riga Stradins Univ, Inst Anat & Anthropol, 16 Dzirciema Str, LV-1007 Riga, Latvia
[2] Riga Tech Univ, Rudolfs Cimdins Riga Biomat Innovat & Dev Ctr RTU, Inst Gen Chem Engn, Fac Mat Sci & Appl Chem, 3 Pulka Str, LV-1007 Riga, Latvia
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 78卷
关键词：
Strontium; Strontium ranelate; Physiology; Bone; Medicine; CALCIUM-SENSING RECEPTOR; BONE-FORMATION; LONG-TERM; POSTMENOPAUSAL WOMEN; OSTEOCLAST FORMATION; VERTEBRAL FRACTURE; CELL REPLICATION; OSTEOPOROSIS; DIFFERENTIATION; MINERALIZATION;
D O I：
10.1016/j.msec.2017.05.042
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The review covers historical and last decade's scientific literature on the biological and clinical role of strontium (Sr) and strontium ranelate (Sr RAN). It enrols the description of the main effects of Sr on supportive tissue, its proven and possible morphopathogenetical mechanisms and the interaction with the bone, and especially focuses on the Sr ability to inhibit osteoclasts and affect the programmed cell death. The main experimental and clinical experience regarding the Sr RAN influence in the treatment of osteoporosis and the search for correct doses is also highlighted. The review gives insight into the role of Sr/Sr RAN on stem cells, apoptosis, animal and clinical research. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：1222 / 1230
页数：9
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