Clinical outcomes are associated with changes in ultrasonographic structural appearance after platelet-rich plasma treatment for knee osteoarthritis

被引:81
作者
Ahmad, Hamada S. [1 ]
Farrag, Sherief E. [1 ]
Okasha, Amr E. [1 ]
Kadry, Aisha O. [2 ]
Ata, Tamer B. [3 ]
Monir, Amir A. [4 ]
Shady, Ibrahim [5 ]
机构
[1] Mansoura Univ, Mansoura Fac Med, Rheumatol & Rehabil Dept, Mansoura, Egypt
[2] Al Azhar Univ, Al Azhar Fac Med, Phys Med Rheumatol & Rehabil, Cairo, Egypt
[3] Mansoura Univ, Mansoura Fac Med, Med Microbiol & Immunol, Mansoura, Egypt
[4] Mansoura Univ, Mansoura Fac Med, Diagnost Radiol, Mansoura, Egypt
[5] Mansoura Univ, Mansoura Fac Med, Community Med Dept, El Gomhouria St, Mansoura 35516, Dakahlia Govern, Egypt
关键词
clinical aspects osteoarthritis; clinical trials; drug treatment osteoarthritis; EVIDENCE-BASED RECOMMENDATIONS; FACTORS PRGF-ENDORET; HYALURONIC-ACID; GROWTH-FACTORS; INTRAARTICULAR INJECTIONS; CARTILAGE REPAIR; DEGENERATION; PATHOGENESIS; PREVALENCE; METAANALYSIS;
D O I
10.1111/1756-185X.13315
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundHyaluronic acid (HA) and platelet-rich plasma (PRP) are two treatment options used for knee osteoarthritis (KOA) but studies comparing the efficacy of the two yield conflicting results. In addition, the association of clinical outcomes of PRP intra-articular injections with changes in the ultrasonography structural appearance of the knee has not been investigated. AimTo compare the efficacy of PRP and HA intra-articular injections as mono-therapeutic options for primary KOA, and to determine whether the clinical outcomes are associated with changes in the ultrasonography structural appearance. Subjects and methodsA randomized clinical trial was conducted on 89 patients with KOA. The patients were given either PRP (n=45) or HA (n=44) intra-articular injections. The patients received three injections in the knee, which was more symptomatic at baseline evaluation, with a 2-week interval between injections. The outcome measures included visual analog score - pain, International Knee Documentation Committee Score, and assessment of synovial hypertrophy, synovial vascularity and knee effusion using ultrasonography. Outcome measures were assessed at baseline and at 3 and 6months post-injection. ResultsWhile both PRP and HA injections resulted in the improvement of all outcome measures at 3 and 6months follow up, they were significantly better in the PRP group than in the HA group. ConclusionIntra-articular injection of PRP is an effective treatment that reduced pain and improved functional status in patients with KOA. The clinical outcomes of the intra-articular injections of PRP are associated with improved synovial hypertrophy and vascularity scores, and less effusion.
引用
收藏
页码:960 / 966
页数:7
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