Endoplasmic reticulum stress induces 5-fluorouracil resistance in human colon cancer cells

被引：40
|
作者：
Kim, Joon Ki [1 ]
Kang, Kyoung Ah [2 ,3 ]
Piao, Mei Jing [2 ,3 ]
Ryu, Yea Seong [2 ,3 ]
Han, Xia [2 ,3 ]
Fernando, Pattage Madushan Dilhara Jayatissa [2 ,3 ]
Oh, Min Chang [2 ,3 ]
Park, Jeong Eon [2 ,3 ]
Shilnikova, Kristina [2 ,3 ]
Boo, Sun Jin [4 ]
Na, Soo-Young [4 ]
Jeong, Yong Joo [1 ]
Jeong, Seung Uk [4 ]
Hyun, Jin Won [2 ,3 ]
机构：
[1] Kookmin Univ, Dept Bio & Nanochem, Seoul 02707, South Korea
[2] Jeju Natl Univ, Sch Med, Jeju 63243, South Korea
[3] Jeju Natl Univ, Inst Nucl Sci & Technol, Jeju 63243, South Korea
[4] Jeju Natl Univ, Sch Med, Jeju 63241, South Korea
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2016年 / 44卷
关键词：
ER stress; 5-FU resistance; Human colon cancer cells; Extracellular signal-regulated kinases; ER stress-related proteins; UNFOLDED PROTEIN RESPONSE; ER STRESS; GRP78; MECHANISMS; SURVIVAL; DEATH; ATF6; AKT; INHIBITION; ACTIVATION;
D O I：
10.1016/j.etap.2016.05.005
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Colon cancer can be treated with 5-fluorouracil (5-FU), but 5-FU resistance frequently occurs. We determined whether 5-FU resistance arises as a result of endoplasmic reticulum (ER) stress. 5-FU-resistant SNUC5 colon cancer cells (SNUC5/FUR cells) expressed higher levels of ER stress-related proteins than drug-sensitive SNUC5 cells. SNUC5/FUR cells also exhibited more intense ER staining and higher level of mitochondrial Ca2+ overload. SNUC5/FUR cells transfected with siRNA against GRP78, ATF6, ERK, or AKT were more sensitive to 5-FU than siControl RNA-transfected cells. These results suggested that 5-FU resistance was associated with ER stress in colon cancer. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：128 / 133
页数：6
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