Anesthesia for patients with congenital Long QT syndrome

被引:104
作者
Kies, SJ
Pabelick, CM
Hurley, HA
White, RD
Ackerman, MJ
机构
[1] Mayo Clin, Coll Med, Dept Anesthesiol, Long QT Syndrome Clin & Sudden Death,Genom Lab, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med, Dept Pediat, Rochester, MN 55905 USA
[3] Mayo Clin, Coll Med, Dept Med, Rochester, MN 55905 USA
[4] Mayo Clin, Coll Med, Dept Mol Pharmacol, Rochester, MN 55905 USA
[5] Mayo Clin, Hosp Pharm Serv, Rochester, MN 55905 USA
关键词
D O I
10.1097/00000542-200501000-00029
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Long QT syndrome is a malfunction of cardiac ion channels resulting in impaired ventricular repolarization that can lead to a characteristic polymorphic ventricular tachycardia known as torsades de pointes. Stressors, by increasing sympathetic tone, and drugs can provoke torsade de pointes, leading to syncope, seizures, or sudden cardiac death in these patients. Beta blockade, implantation of cardioverter defibrillators, and left cardiac sympathetic denervation are used in the treatment of these patients. However, these treatment modalities do not guarantee the prevention of sudden cardiac death. Certain drugs, including anesthetic agents, are known to contribute to QT prolongation. After reviewing the literature the authors give recommendations for the anesthetic management of these patients in the perioperative period.
引用
收藏
页码:204 / 210
页数:7
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