Synthesis of Fe3O4@SiO2@polymer nanoparticles for controlled drug release

被引：30

作者：

Wu ChengLin

He Huan

Gao HongJun

Liu Gan

Ma RuJiang

An YingLi

Shi LinQi ^{[1
]}

机构：

[1] Nankai Univ, Minist Educ, Key Lab Funct Polymer Mat, Tianjin 300071, Peoples R China

来源：

SCIENCE CHINA-CHEMISTRY | 2010年 / 53卷 / 03期

基金：

中国国家自然科学基金;

关键词：

magnetic nanoparticle; Fe3O4@SiO2; multifunctional; controlled drug release; IRON-OXIDE NANOPARTICLES; SHELL;

D O I：

10.1007/s11426-010-0084-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel multifunctional nanoparticles containing a magnetic Fe3O4@SiO2 sphere and a biocompatible block copolymer poly(ethylene glycol)-b-poly(aspartate) (PEG-b-PAsp) were prepared. The silica coated on the superparamagnetic core was able to achieve a magnetic dispersivity, as well as to protect Fe3O4 against oxidation and acid corrosion. The PAsp block was grafted to the surface of Fe3O4@SiO2 nanoparticles by amido bonds, and the PEG block formed the outermost shell. The anticancer agent doxorubicin (DOX) was loaded into the hybrid nanoparticles via an electrostatic interaction between DOX and PAsp. The release rate of DOX could be adjusted by the pH value.

引用

收藏

页码：514 / 518

页数：5

相关论文

共 21 条

[1] A new drug carrier: Magnetite nanoparticles coated with amphiphilic block copolymer [J].

Chang Yu ;

Bai YunPeng ;

Teng Bao ;

Li ZhaoLong .

CHINESE SCIENCE BULLETIN, 2009, 54 (07) :1190-1196

[2] The grafting and release behavior of doxorubincin from Fe3O4@SiO2 core-shell structure nanoparticles via an acid cleaving amide bond:: the potential for magnetic targeting drug delivery [J].

Chen, F. H. ;

Gao, Q. ;

Ni, J. Z. .

NANOTECHNOLOGY, 2008, 19 (16)

[3]

FU FX, 2006, BIOMATERIALS, V27, P5725

[4] Magnetic and pH-responsive nanocarriers with multilayer core-shell architecture for anticancer drug delivery [J].

Guo, Miao ;

Yan, Yu ;

Zhang, Hongkai ;

Yan, Husheng ;

Cao, Youjia ;

Liu, Keliang ;

Wan, Shourong ;

Huang, Junsheng ;

Yue, Wei .

JOURNAL OF MATERIALS CHEMISTRY, 2008, 18 (42) :5104-5112

[5] Synthesis of Folic Acid Functionalized PLLA-b-PPEGMA Nanoparticles for Cancer Cell Targeting [J].

Hu, Feixiong ;

Neoh, Koon Gee ;

Kang, En-Tang .

MACROMOLECULAR RAPID COMMUNICATIONS, 2009, 30 (08) :609-614

[6] Magnetic fluorescent delivery vehicle using uniform mesoporous silica spheres embedded with monodisperse magnetic and semiconductor nanocrystals [J].

Kim, J ;

Lee, JE ;

Lee, J ;

Yu, JH ;

Kim, BC ;

An, K ;

Hwang, Y ;

Shin, CH ;

Park, JG ;

Kim, J ;

Hyeon, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (03) :688-689

[7] Enzymatic clipping of DNA wires coated with magnetic nanoparticles [J].

Kinsella, JM ;

Ivanisevic, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (10) :3276-3277

[8] Magnetic nanoparticles:: Synthesis, protection, functionalization, and application [J].

Lu, An-Hui ;

Salabas, E. L. ;

Schueth, Ferdi .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (08) :1222-1244

[9] Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging [J].

Lu, Jian ;

Ma, Shuli ;

Sun, Jiayu ;

Xia, Chunchao ;

Liu, Chen ;

Wang, Zhiyong ;

Zhao, Xuna ;

Gao, Fabao ;

Gong, Qiyong ;

Song, Bin ;

Shuai, Xintao ;

Ai, Hua ;

Gu, Zhongwei .

BIOMATERIALS, 2009, 30 (15) :2919-2928

[10] Modifying the surface properties of superparamagnetic iron oxide nanoparticles through a sol-gel approach [J].

Lu, Y ;

Yin, YD ;

Mayers, BT ;

Xia, YN .

NANO LETTERS, 2002, 2 (03) :183-186