Role of the microbiome in occurrence, development and treatment of pancreatic cancer

被引：88

作者：

Wang, Yicheng ^{[1
]}

Yang, Gang ^{[1
]}

You, Lei ^{[1
]}

Yang, Jinshou ^{[1
]}

Feng, Mengyu ^{[1
]}

Qiu, Jiangdong ^{[1
]}

Zhao, Fangyu ^{[1
]}

Liu, Yueze ^{[1
]}

Cao, Zhe ^{[1
]}

Zheng, Lianfang ^{[2
]}

Zhang, Taiping ^{[1
,3
]}

Zhao, Yupei ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Gen Surg, Peking Union Med Coll Hosp, 1 Shuaifuyuan,Wangfujing St, Beijing 100730, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Dept Nucl Med, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Clin Immunol Ctr, Beijing 100730, Peoples R China

来源：

MOLECULAR CANCER | 2019年 / 18卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Pancreatic cancer; Microbiomes; Chemotherapy; Diagnosis; HELICOBACTER-PYLORI INFECTION; GUT MICROBIOTA; INTESTINAL MICROBIOTA; ORAL MICROBIOTA; POTENTIAL ROLE; RECEPTOR; RISK; OBESITY; ASSOCIATION; INFLAMMATION;

D O I：

10.1186/s12943-019-1103-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pancreatic cancer is one of the most lethal malignancies. Recent studies indicated that development of pancreatic cancer may be intimately connected with the microbiome. In this review, we discuss the mechanisms through which microbiomes affect the development of pancreatic cancer, including inflammation and immunomodulation. Potential therapeutic and diagnostic applications of microbiomes are also discussed. For example, microbiomes may serve as diagnostic markers for pancreatic cancer, and may also play an important role in determining the efficacies of treatments such as chemo- and immunotherapies. Future studies will provide additional insights into the various roles of microbiomes in pancreatic cancer.

引用

页数：13

共 171 条

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