The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting iASPP

被引：82
作者：
He, Zongze [1 ,2 ]
Wang, Yujue [3 ]
Huang, Guangfu [1 ,2 ]
Wang, Qi [1 ,2 ]
Zhao, Dongdong [1 ,2 ]
Chen, Longyi [1 ,2 ]
机构：
[1] Univ Elect Sci & Technol China, Dept Neurosurg, Hosp, 32 West Second Sect,First Ring Rd, Chengdu 610072, Sichuan Provinc, Peoples R China
[2] Sichuan Prov Peoples Hosp, 32 West Second Sect,First Ring Rd, Chengdu 610072, Sichuan Provinc, Peoples R China
[3] Kai Luan Gen Hosp, Dept Neurosurg, Tangshan City 063000, Hebei Province, Peoples R China
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2017年 / 623卷
关键词：
MiR-182; Glioma; Proliferation; Migration; iASPP; Long non-coding RNA; LONG NONCODING RNA; BLADDER-CANCER CELLS; TUMOR-SUPPRESSOR; KIDNEY CANCER; EXPRESSION; APOPTOSIS; GROWTH; RESISTANCE; PROSTATE;
D O I：
10.1016/j.abb.2017.01.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long non-coding RNA (IncRNA) urothelial carcinoma associated 1 (UCA1) has been reported to be involved in the development and progression of many types of tumors including breast cancer, gastric cancer, and bladder cancer. However, the exact effects and molecular mechanisms of UCA1 in glioma progression remain unclear up to now. In this study, we firstly found that UCA1 was upregulated in glioma tumor samples and negatively correlated with survival time. Then, we investigated the role of UCA1 in human glioma cell lines. Our results showed that upregulation of IncRNA-UCA1 in glioma tissues and cell lines could promote glioma cell proliferation and migration through interaction with miR-182, and knockdown of UCA1 inhibited the proliferation and migration of human glioma cell. In addition, miR-182 dependent inhibitor of apoptosis-stimulating protein of p53 (iASPP) was required in the regulation of UCA1 induced glioma cell proliferation. Taken together, UCA1 might promote proliferation and migration of glioma, to regulate the tumor growth and metastasis via miR-182 dependent iASPP regulation. Therefore, IncRNA-UCA1 could be regarded as a therapeutic target in human glioma. (C) 2017 Published by Elsevier Inc.
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页码：1 / 8
页数：8
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