Morphology and physiology of the blood-brain barrier

被引：3

作者：

Copin, JC ^{[1
]}

Gasche, Y ^{[1
]}

机构：

[1] Hop Univ Geneve, Div Soins Intens Chirurg & Med, Div Invest Anesthesiol, CH-1211 Geneva, Switzerland

来源：

ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION | 2003年 / 22卷 / 03期

关键词：

blood-brain barrier; tight junction; transport; enclothelial cell; astrocyte; pericytes;

D O I：

10.1016/S0750-7658(03)00040-6

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The blood-brain barrier (BBB) is a complex biological system that consists of endothelial cells, pericytes and astrocytes, which are involved in the induction and maintenance of its physiological and ultrastructural characteristics. The BBB plays a primordial role in isolating the cerebral parenchyma as well as in controlling brain homeostasis by its selective permeability to nutriments and other molecules flowing through the cerebral microcapillaries. A better knowledge of this system is crucial in order to improve the efficiency of brain penetration by drugs, and in order to prevent BBB opening, leading to brain edema, in physiopathological situations such as brain ischemia, trauma or inflammatory processes. (C) 2003 editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：202 / 214

页数：13

共 167 条

[1] Activated T-lymphocytes express occludin, a component of tight junctions [J].