Maslinic acid as an effective anticancer agent

被引：18

作者：

Lin, Xiukun ^{[1
]}

Ozbey, Ulku ^{[2
]}

Sabitaliyevich, Uteuliyev Yerzhan ^{[3
]}

Attar, Rukset ^{[4
]}

Ozcelik, Beraat ^{[5
]}

Zhang, Yuanyan ^{[1
]}

Guo, Mingyue ^{[1
]}

Liu, Minghua ^{[1
]}

Alhewairini, Saleh S. ^{[6
]}

Farooqi, Ammad Ahmad ^{[7
]}

机构：

[1] Southwest Med Univ, Dept Pharmacol, Luzhou 646000, Sichuan, Peoples R China

[2] Munzur Univ, Hlth High Sch, Dept Genet, TR-62000 Tunceli, Turkey

[3] Kazakhstan Med Univ KSPH, Alma Ata, Kazakhstan

[4] Yeditepe Univ, Dept Obstet & Gynecol, Istanbul, Turkey

[5] Istanbul Tech Univ, Food Engn Dept, TR-34469 Istanbul, Turkey

[6] Qassim Univ, Coll Agr & Vet Med, Dept Plant Prod & Protect, POB 6622, Buraydah 51452, Al Qassim, Saudi Arabia

[7] IBGE, Islamabad, Pakistan

来源：

CELLULAR AND MOLECULAR BIOLOGY | 2018年 / 64卷 / 10期

关键词：

Cancer; Signaling; Apoptosis; Maslinic Acid; CANCER CELLS; LUNG-CANCER; NATURAL-PRODUCTS; OLEANOLIC ACID; GASTRIC-CANCER; IN-VITRO; APOPTOSIS; SUPPRESSES; PROLIFERATION; TRITERPENES;

D O I：

10.14715/cmb/2018.64.10.14

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Maslinic acid (2 alpha,3 beta-dihydroxyolean-12-en-28-oic acid) is a naturally occurring pentacyclic triterpenic compound. Maslinic acid is gradually gaining attention as an excellent pharmacologically active product because of its premium biological properties. In this review we will focus on chemopreventive properties of Maslinic acid against different cancers. Seemingly, available data is limited and we have yet to unravel how Maslinic acid therapeutically targeted oncogenic cell signal transduction cascades in different cancers. Moreover, there are visible knowledge gaps about the ability of Maslinic acid to modulate oncogenic and tumor suppressor microRNAs in various cancers.

引用

页码：87 / 91

页数：5

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