Virulence of the zoonotic agent of leptospirosis: still terra incognita?

被引：252
作者：
Picardeau, Mathieu [1 ,2 ]
机构：
[1] Inst Pasteur, Biol Spirochetes Unit, Natl Reference Ctr, 28 Rue Docteur Roux, F-75724 Paris 15, France
[2] WHO Collaborating Ctr Leptospirosis, 28 Rue Docteur Roux, F-75724 Paris 15, France
来源：
NATURE REVIEWS MICROBIOLOGY | 2017年 / 15卷 / 05期
关键词：
OUTER-MEMBRANE PROTEIN; FIELD GEL-ELECTROPHORESIS; PATHOGENIC LEPTOSPIRA; FAMILY LEPTOSPIRACEAE; COMPLEMENT REGULATORS; PERIPLASMIC FLAGELLA; RENAL COLONIZATION; SECRETION SYSTEMS; INTERROGANS; MOTILITY;
D O I：
10.1038/nrmicro.2017.5
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Pathogenic leptospires are the bacterial agents of leptospirosis, which is an emerging zoonotic disease that affects animals and humans worldwide. The success of leptospires as pathogens is explained by their spiral shape and endoflagellar motility (which enable these spirochetes to rapidly cross connective tissues and barriers), as well as by their ability to escape or hijack the host immune system. However, the basic biology and virulence factors of leptospires remain poorly characterized. In this Review, we discuss the recent advances in our understanding of the epidemiology, taxonomy, genomics and the molecular basis of virulence in leptospires, and how these properties contribute to the mechanism of pathogenesis of leptospirosis.
引用
收藏
页码：297 / 307
页数：11
相关论文
共 126 条
[81]   Borrelia burgdorferi periplasmic flagella have both skeletal and motility functions [J].
Motaleb, MA ;
Corum, L ;
Bono, JL ;
Elias, AF ;
Rosa, P ;
Samuels, DS ;
Charon, NW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (20) :10899-10904
[82]   The Molecular Basis of Leptospiral Pathogenesis [J].
Murray, Gerald L. .
LEPTOSPIRA AND LEPTOSPIROSIS, 2015, 387 :139-185
[83]   Leptospira interrogans requires heme oxygenase for disease pathogenesis [J].
Murray, Gerald L. ;
Srikram, Arnporn ;
Henry, Rebekah ;
Puapairoj, Anucha ;
Sermswan, Rasana W. ;
Adler, Ben .
MICROBES AND INFECTION, 2009, 11 (02) :311-314
[84]   Major Surface Protein LipL32 Is Not Required for Either Acute or Chronic Infection with Leptospira interrogans [J].
Murray, Gerald L. ;
Srikram, Amporn ;
Hoke, David E. ;
Wunder, Elsio A., Jr. ;
Henry, Rebekah ;
Lo, Miranda ;
Zhang, Kunkun ;
Sermswan, Rasana W. ;
Ko, Albert I. ;
Adler, Ben .
INFECTION AND IMMUNITY, 2009, 77 (03) :952-958
[85]   Environmental and Behavioural Determinants of Leptospirosis Transmission: A Systematic Review [J].
Mwachui, Mwanajaa Abdalla ;
Crump, Lisa ;
Hartskeerl, Rudy ;
Zinsstag, Jakob ;
Hattendorf, Jan .
PLOS NEGLECTED TROPICAL DISEASES, 2015, 9 (09)
[86]   Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in muine and human cells [J].
Nahori, MA ;
Fournié-Amazouz, E ;
Que-Gewirth, NS ;
Balloy, V ;
Chignard, M ;
Raetz, CRH ;
Saint Girons, I ;
Werts, C .
JOURNAL OF IMMUNOLOGY, 2005, 175 (09) :6022-6031
[87]   Direct Measurement of Helical Cell Motion of the Spirochete Leptospira [J].
Nakamura, Shuichi ;
Leshansky, Alexander ;
Magariyama, Yukio ;
Namba, Keiichi ;
Kudo, Seishi .
BIOPHYSICAL JOURNAL, 2014, 106 (01) :47-54
[88]   Changes in lipopolysaccharide O antigen distinguish acute versus chronic Leptospira interrogans infections [J].
Nally, JE ;
Chow, E ;
Fishbein, MC ;
Blanco, DR ;
Lovett, MA .
INFECTION AND IMMUNITY, 2005, 73 (06) :3251-3260
[89]   Role of sph2 Gene Regulation in Hemolytic and Sphingomyelinase Activities Produced by Leptospira interrogans [J].
Narayanavari, Suneel A. ;
Lourdault, Kristel ;
Sritharan, Manjula ;
Haake, David A. ;
Matsunaga, James .
PLOS NEGLECTED TROPICAL DISEASES, 2015, 9 (08)
[90]   Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis [J].
Needham, Brittany D. ;
Trent, M. Stephen .
NATURE REVIEWS MICROBIOLOGY, 2013, 11 (07) :467-481
45678910111213