Virulence of the zoonotic agent of leptospirosis: still terra incognita?

被引：252

作者：

Picardeau, Mathieu ^{[1
,2
]}

机构：

[1] Inst Pasteur, Biol Spirochetes Unit, Natl Reference Ctr, 28 Rue Docteur Roux, F-75724 Paris 15, France

[2] WHO Collaborating Ctr Leptospirosis, 28 Rue Docteur Roux, F-75724 Paris 15, France

来源：

NATURE REVIEWS MICROBIOLOGY | 2017年 / 15卷 / 05期

关键词：

OUTER-MEMBRANE PROTEIN; FIELD GEL-ELECTROPHORESIS; PATHOGENIC LEPTOSPIRA; FAMILY LEPTOSPIRACEAE; COMPLEMENT REGULATORS; PERIPLASMIC FLAGELLA; RENAL COLONIZATION; SECRETION SYSTEMS; INTERROGANS; MOTILITY;

D O I：

10.1038/nrmicro.2017.5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pathogenic leptospires are the bacterial agents of leptospirosis, which is an emerging zoonotic disease that affects animals and humans worldwide. The success of leptospires as pathogens is explained by their spiral shape and endoflagellar motility (which enable these spirochetes to rapidly cross connective tissues and barriers), as well as by their ability to escape or hijack the host immune system. However, the basic biology and virulence factors of leptospires remain poorly characterized. In this Review, we discuss the recent advances in our understanding of the epidemiology, taxonomy, genomics and the molecular basis of virulence in leptospires, and how these properties contribute to the mechanism of pathogenesis of leptospirosis.

引用

页码：297 / 307

页数：11

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