Lectins with Anti-HIV Activity: A Review

被引：86

作者：

Akkouh, Ouafae ^{[1
]}

Ng, Tzi Bun ^{[2
]}

Singh, Senjam Sunil ^{[3
]}

Yin, Cuiming ^{[2
]}

Dan, Xiuli ^{[2
]}

Chan, Yau Sang ^{[2
]}

Pan, Wenliang ^{[2
]}

Cheung, Randy Chi Fai ^{[2
]}

机构：

[1] Univ Appl Sci Leiden, Fac Technol, Dept Biol & Med Lab Res, NL-2333 CK Leiden, Netherlands

[2] Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Shatin, Hong Kong, Peoples R China

[3] Manipur Univ, Dept Biochem, Imphal 795003, Manipur, India

来源：

MOLECULES | 2015年 / 20卷 / 01期

关键词：

lectins; anti-HIV; worm; cyanobacteria; actinomycete; HUMAN-IMMUNODEFICIENCY-VIRUS; ENVELOPE GLYCOPROTEIN GP120; CARBOHYDRATE-BINDING SITES; CYANOVIRIN-N; ENTRY INHIBITOR; IN-VITRO; INACTIVATING PROTEIN; MOLECULAR-MECHANISMS; INDUCED APOPTOSIS; ALGAL LECTINS;

D O I：

10.3390/molecules20010648

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lectins including flowering plant lectins, algal lectins, cyanobacterial lectins, actinomycete lectin, worm lectins, and the nonpeptidic lectin mimics pradimicins and benanomicins, exhibit anti-HIV activity. The anti-HIV plant lectins include Artocarpus heterophyllus (jacalin) lectin, concanavalin A, Galanthus nivalis (snowdrop) agglutinin-related lectins, Musa acuminata (banana) lectin, Myrianthus holstii lectin, Narcissus pseudonarcissus lectin, and Urtica diocia agglutinin. The anti-HIV algal lectins comprise Boodlea coacta lectin, Griffithsin, Oscillatoria agardhii agglutinin. The anti-HIV cyanobacterial lectins are cyanovirin-N, scytovirin, Microcystis viridis lectin, and microvirin. Actinohivin is an anti-HIV actinomycete lectin. The anti-HIV worm lectins include Chaetopterus variopedatus polychaete marine worm lectin, Serpula vermicularis sea worm lectin, and C-type lectin Mermaid from nematode (Laxus oneistus). The anti-HIV nonpeptidic lectin mimics comprise pradimicins and benanomicins. Their anti-HIV mechanisms are discussed.

引用

页码：648 / 668

页数：21

共 109 条

[1] Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN [J].

Alexandre, Kabamba B. ;

Moore, Penny L. ;

Nonyane, Molati ;

Gray, Elin S. ;

Ranchobe, Nthabeleng ;

Chakauya, Ereck ;

McMahon, James B. ;

O'Keefe, Barry R. ;

Chikwamba, Rachel ;

Morris, Lynn .

VIROLOGY, 2013, 446 (1-2) :66-76

[2] Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin [J].

Alexandre, Kabamba B. ;

Gray, Elin S. ;

Lambson, Bronwen E. ;

Moore, Penny L. ;

Choge, Isaac A. ;

Mlisana, Koleka ;

Karim, Salim S. Abdool ;

McMahon, James ;

O'Keefe, Barry ;

Chikwamba, Rachel ;

Morris, Lynn .

VIROLOGY, 2010, 402 (01) :187-196

[3] Binding of the Mannose-Specific Lectin, Griffithsin, to HIV-1 gp120 Exposes the CD4-Binding Site [J].

Alexandre, Kabamba Bankoledi ;

Gray, Elin S. ;

Pantophlet, Ralph ;

Moore, Penny L. ;

McMahon, James B. ;

Chakauya, Ereck ;

O'Keefe, Barry R. ;

Chikwamba, Rachel ;

Morris, Lynn .

JOURNAL OF VIROLOGY, 2011, 85 (17) :9039-9050

[4] Inhibition of HIV entry by carbohydrate-binding proteins [J].

Balzarini, J. .

ANTIVIRAL RESEARCH, 2006, 71 (2-3) :237-247

[5] THE MANNOSE-SPECIFIC PLANT-LECTINS FROM CYMBIDIUM HYBRID AND EPIPACTIS-HELLEBORINE AND THE (N-ACETYLGLUCOSAMINE)N-SPECIFIC PLANT LECTIN FROM URTICA-DIOICA ARE POTENT AND SELECTIVE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS AND CYTOMEGALOVIRUS REPLICATION INVITRO [J].

BALZARINI, J ;

NEYTS, J ;

SCHOLS, D ;

HOSOYA, M ;

VANDAMME, E ;

PEUMANS, W ;

DECLERCQ, E .

ANTIVIRAL RESEARCH, 1992, 18 (02) :191-207

[6] Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy [J].

Balzarini, Jan .

NATURE REVIEWS MICROBIOLOGY, 2007, 5 (08) :583-597

[7] Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytes [J].

Balzarini, Jan ;

Van Herrewege, Yven ;

Vermeire, Kurt ;

Vanham, Guido ;

Schols, Dominique .

MOLECULAR PHARMACOLOGY, 2007, 71 (01) :3-11

[8] Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes [J].

Balzarini, Jan ;

Van Laethem, Kristel ;

Peumans, Willy J. ;

Van Damme, Els J. M. ;

Bolmstedt, Anders ;

Gago, Federico ;

Schols, Dominique .

JOURNAL OF VIROLOGY, 2006, 80 (17) :8411-8421

[9] PREPARATION AND X-RAY CHARACTERIZATION OF 4 NEW CRYSTAL FORMS OF JACALIN, A LECTIN FROM ARTOCARPUS-INTEGRIFOLIA [J].

BANERJEE, R ;

DHANARAJ, V ;

MAHANTA, SK ;

SUROLIA, A ;

VIJAYAN, M .

JOURNAL OF MOLECULAR BIOLOGY, 1991, 221 (03) :773-776

[10] New carbohydrate specificity and HIV-1 fusion blocking activity of the cyanobacteirial protein MVL:NMR, ITC and sedimentation equilibrium studies [J].

Bewley, CA ;

Cai, ML ;

Ray, S ;

Ghirando, R ;

Yamaguchi, M ;

Muramoto, K .

JOURNAL OF MOLECULAR BIOLOGY, 2004, 339 (04) :901-914

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