Hits and defeats of genome-wide association studies of atopy and asthma

被引：2

作者：

Danielewicz, Hanna ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept & Clin Pediat Allergol & Cardiol 1, Ul Chalubinskiego 2a, PL-50360 Wroclaw, Poland

来源：

JOURNAL OF APPLIED BIOMEDICINE | 2017年 / 15卷 / 03期

关键词：

GWAS; Asthma; Atopy; Gene-environment; Epigenetics; Farming; GENETIC RISK-FACTORS; SUSCEPTIBILITY LOCI; METAANALYSIS; VARIANTS; CHILDHOOD; EPIGENETICS; EXPOSURE; METHYLATION; CHILDREN; CTNNA3;

D O I：

10.1016/j.jab.2017.03.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Atopy and asthma are complex conditions, recognised as outcomes in which both genes and environment play crucial role. Large number of disease associated loci have been identified within GWAS approach over last years and the knowledge of pathobiology of asthma and allergy has widened substantially. However still the results achieved are difficult to interpret. Most markers have no clear function on and expound small portion of heritability. The "missed heritability" could be hidden in the gene-by environment interactions. The most know environmental factor which interacts with asthma and atopy is farming. The common link between genes and environment could be epigenetics. (C) 2017 Faculty of Health and Social Sciences, University of South Bohemia in Ceske Budejovice. Published by Elsevier Sp. z o.o. All rights reserved.

引用

页码：161 / 168

页数：8

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