Soy Isoflavones and Gastrointestinal Health

被引：25
作者：
Al-Nakkash, Layla [1 ,2 ]
Kubinski, Aaron [2 ]
机构：
[1] Midwestern Univ, Coll Grad Studies, Glendale, AZ 85308 USA
[2] Midwestern Univ, Arizona Coll Osteopath Med, Glendale, AZ 85308 USA
来源：
CURRENT NUTRITION REPORTS | 2020年 / 9卷 / 03期
关键词：
Soy isoflavones; Genistein; Apigenin; Quercetin; Gastrointestine; Small intestine; Colon; Gut health; Secretion; Motility; Contractility; Epithelial barrier; Tight junctions; Inflammation; Intestinal disease; Mouse models; Colitis; Cystic fibrosis; Diabetes; ELECTROGENIC CL-SECRETION; NF-KAPPA-B; INTERSTITIAL-CELLS; CHLORIDE SECRETION; OXIDATIVE STRESS; BARRIER FUNCTION; GENISTEIN; JEJUNUM; INFLAMMATION; INHIBITION;
D O I：
10.1007/s13668-020-00314-4
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Purpose of Review Soy isoflavones are known to have beneficial effects on several aspects of gastrointestinal physiological functions (contractility or motility, secretion, morphology, and barrier function). In this review, we discuss the effects of soy isoflavones on the overall gut function and inflammation and assess how these effects might be implicated in the treatment of several gut-related diseases. Recent Findings Soy isoflavones influence several key aspects of gastrointestinal health: improve basal intestinal secretion, alleviate inflammation, limit intestinal morphological damage, and improve epithelial barrier function in several clinically relevant murine models of gastrointestinal diseases. Summary Dietary supplementation with isoflavones proves to be a key means to improve the overall gut function and health. Future mechanistic studies with isoflavone interventions will help treat clinically related diseases such as cystic fibrosis and inflammatory-related gut problems such as colitis and diabetes.
引用
收藏
页码：193 / 201
页数：9
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