Percutaneous absorption and exposure assessment of pesticides

被引：40
作者：
Ngo, Mai A. [1 ]
O'Malley, Michael [1 ,2 ]
Maibach, Howard I. [3 ]
机构：
[1] Calif EPA, Dept Pesticide Regulat, Sacramento, CA 95812 USA
[2] Univ Calif Davis, Davis, CA 95616 USA
[3] Univ Calif San Francisco, San Francisco, CA 94143 USA
来源：
JOURNAL OF APPLIED TOXICOLOGY | 2010年 / 30卷 / 02期
关键词：
in vitro; in vivo; dermal; skin; QSAR; HUMAN STRATUM-CORNEUM; EPIDERMAL WATER-LOSS; SODIUM LAURYL SULFATE; PREDICTING SKIN PERMEABILITY; COMPLEX CHEMICAL-MIXTURES; SLIGHTLY DAMAGED SKIN; VELLUS HAIR FOLLICLE; IN-VITRO MODEL; DERMAL ABSORPTION; BARRIER FUNCTION;
D O I：
10.1002/jat.1505
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Dermal exposure to a diverse range of chemicals may result from various uses. In order to assess exposure and estimate potential risks, accurate quantitative data on absorption are required. Various factors will influence the final results and interpretations of studies designed to assess the ability of compounds to penetrate the skin. This overview will discuss skin penetration by pesticides, emphasizing key parameters to be considered from the perspective of exposure assessment. Copyright (C) 2009 John Wiley & Sons, Ltd.
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页码：91 / 114
页数：24
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