Tamoxifen and oxidative stress: an overlooked connection

被引：24

作者：

Ahmed, Nermin S. ^{[1
]}

Samec, Marek ^{[2
]}

Liskova, Alena ^{[2
]}

Kubatka, Peter ^{[3
]}

Saso, Luciano ^{[4
]}

机构：

[1] German Univ Cairo, Fac Pharm & Biotechnol, Dept Pharmaceut Chem, Cairo 11835, Egypt

[2] Comenius Univ, Jessenius Fac Med, Dept Obstet & Gynecol, Martin 03601, Slovakia

[3] Comenius Univ, Jessenius Fac Med, Dept Med Biol, Dept Expt Carcinogenesis,Biomed Ctr Martin,Div On, Mala Hora 4, Martin 03601, Slovakia

[4] Sapienza Univ, Dept Physiol & Pharmacol Vittorio Erspamer, Ple Aldo Moro 5, I-00185 Rome, Italy

来源：

DISCOVER ONCOLOGY | 2021年 / 12卷 / 01期

关键词：

Apoptosis; ER; Oxidative stress; Resistance; Tamoxifen; PROTEIN-KINASE-C; BREAST-CANCER CELLS; ESTROGEN-RECEPTOR-ALPHA; ACQUIRED ENDOCRINE RESISTANCE; ANTICANCER DRUG TAMOXIFEN; POSTMENOPAUSAL WOMEN; INDUCED APOPTOSIS; INDUCED HEPATOTOXICITY; CYP2D6; POLYMORPHISMS; MULTIDRUG-RESISTANCE;

D O I：

10.1007/s12672-021-00411-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress.

引用

页数：15

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