Successful Treatment of Antibiotic-resistant, Poly-microbial Bone Infection With Bacteriophages and Antibiotics Combination

被引：185

作者：

Nir-Paz, Ran ^{[1
]}

Gelman, Daniel ^{[2
,3
]}

Khouri, Ayman ^{[4
]}

Sisson, Brittany M. ^{[5
]}

Fackler, Joseph ^{[5
]}

Alkalay-Oren, Sivan ^{[2
]}

Khalifa, Leron ^{[2
]}

Rimon, Amit ^{[2
,3
]}

Yerushalmy, Ortal ^{[2
]}

Bader, Reem ^{[1
]}

Amit, Sharon ^{[1
]}

Coppenhagen-Glazer, Shunit ^{[2
]}

Henry, Matthew ^{[6
,7
]}

Quinones, Javier ^{[6
,7
]}

Malagon, Francisco ^{[6
,7
]}

Biswas, Biswajit ^{[6
,7
]}

Moses, Allon E. ^{[1
]}

Merril, Greg ^{[5
]}

Schooley, Robert T. ^{[8
]}

Brownstein, Michael J. ^{[5
]}

Weil, Yoram A. ^{[4
]}

Hazan, Ronen ^{[2
]}

机构：

[1] Hadassah Hebrew Univ, Med Ctr, Dept Clin Microbiol & Infect Dis, Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Fac Med Dent, Inst Dent Sci, Jerusalem, Israel

[3] Hebrew Univ Jerusalem, Hadassah Med Sch, Mil Track Med, Jerusalem, Israel

[4] Hadassah Hebrew Univ, Med Ctr, Orthoped Surg Dept, Jerusalem, Israel

[5] Adapt Phage Therapeut, Gaithersburg, MD USA

[6] Geneva Fdn, Frederick, MD USA

[7] Naval Med Res Ctr, Biol Def Res Directorate, Frederick, MD USA

[8] Univ Calif San Diego, Dept Med, Div Infect Dis, La Jolla, CA 92093 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2019年 / 69卷 / 11期

基金：

以色列科学基金会;

关键词：

bacteriophage; phage; phage therapy; antibiotic resistance; orthopedic infections;

D O I：

10.1093/cid/ciz222

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A patient with a trauma-related left tibial infection associated with extensively drug-resistant Acinetobacter baumannii and multidrug-resistant Klebsiella pneumoniae was treated with bacteriophages and antibiotics. There was rapid tissue healing and positive culture eradication. As a result, the patient's leg did not have to be amputated and he is undergoing rehabilitation.

引用

页码：2015 / 2018

页数：4

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