Scaffold-free cell delivery for use in regenerative medicine

被引：95
作者：
Kelm, Jens M. [2 ,3 ]
Fussenegger, Martin [1 ,4 ]
机构：
[1] Fed Inst Technol Zurich, Dept Biosyst Sci & Engn, CH-4058 Basel, Switzerland
[2] Univ Zurich, VetSuisse Fac, Competence Ctr Appl Biotechnol & Mol Med, CH-8057 Zurich, Switzerland
[3] Univ Zurich, Dept Surg Res, Regenerat Med Program, CH-8091 Zurich, Switzerland
[4] Univ Basel, CH-4058 Basel, Switzerland
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 7-8期
关键词：
Stem cells; Cell sheets; Microtissues; Tissue engineering; MESENCHYMAL STEM-CELLS; ENDOTHELIAL PROGENITOR CELLS; IMPROVE CARDIAC-FUNCTION; MARROW STROMAL CELLS; LONG-TERM SURVIVAL; GROWTH-FACTOR; PERIODONTAL REGENERATION; MYOCARDIAL-INFARCTION; ARTICULAR-CARTILAGE; INTERVERTEBRAL DISC;
D O I：
10.1016/j.addr.2010.02.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The development of cell-based therapies for diseased tissues is one of the most promising research directions in regenerative medicine. Cell-delivery methods are an essential part of cell therapy concepts. Therapies with the potential to become clinical routine will only be possible if these methods ensure efficient engraftment and therapeutically-relevant number of cells survive. Here we provide an overview of three different scaffold-free cell-delivery concepts: (i) single cell delivery, (ii) cell sheet engineering and (iii) microtissue technology. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：753 / 764
页数：12
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