Identification of Preferentially Expressed Antigen of Melanoma as a Potential Tumor Suppressor in Lung Adenocarcinoma

被引：4

作者：

Huang, Quan ^{[1
]}

Li, Lin ^{[1
]}

Lin, Zaijun ^{[1
]}

Xu, Wei ^{[1
]}

Han, Shuai ^{[1
]}

Zhao, Chenglong ^{[1
]}

Li, Lei ^{[1
]}

Cao, Wenjiao ^{[2
]}

Yang, Xinghai ^{[1
]}

Wei, Haifeng ^{[1
]}

Xiao, Jianru ^{[1
]}

机构：

[1] Second Mil Med Univ, Changzheng Hosp, Dept Orthoped Oncol, Shanghai, Peoples R China

[2] China Welf Inst IPMCH, Int Peace Matern & Child Hlth Hosp, Shanghai, Peoples R China

来源：

MEDICAL SCIENCE MONITOR | 2016年 / 22卷

关键词：

Apoptosis; Cell Proliferation; Lung Diseases; PRAME EXPRESSION; CELL-PROLIFERATION; CANCER; OSTEOSARCOMA; APOPTOSIS; RECEPTOR; HYPOXIA; ARREST; GENE; P53;

D O I：

10.12659/MSM.895642

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: Preferentially expressed antigen of melanoma (PRAME) is known as a tumor-associated antigen that is altered in a variety of malignancies, including lung cancer. However, the role of PRAME in lung cancer remains unclear. Material/Methods: We analyzed the expression of PRAME in human lung adenocarcinomas and studied the function of PRAME using small interfering RNA (siRNA)-induced gene knockdown in lung cancer cell lines PC9 and A549. Results: We found that PRAME expression is down-regulated in lung adenocarcinomas. Knockdown of PRAME promoted proliferation and suppressed apoptosis of PC9 and A549 cells. Conclusions: In line with its roles in controlling cell growth, RPAME regulates multiple critical cell-growth related genes, including IGF1R oncogene. IGF1R up-regulation contributes to increase of cell growth upon the knockdown of PRAME. Taken together, our results suggest that PRAME has inhibitory roles in lung cancer.

引用

页码：1837 / 1842

页数：6

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