Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

被引：399

作者：

Ben Sahra, Issam ^{[1
,2
]}

Le Marchand-Brustel, Yannick ^{[1
,2
,3
]}

Tanti, Jean-Francois ^{[1
,2
]}

Bost, Frederic ^{[1
,2
]}

机构：

[1] INSERM, U895, Team Cellular & Mol Physiopathol Obes & Diabet 7, F-06204 Nice 3, France

[2] Univ Nice Sophia Antipolis, UFR Med, IFR 50, Nice, France

[3] Hop Archet, Ctr Hosp Univ Nice, Nice, France

来源：

MOLECULAR CANCER THERAPEUTICS | 2010年 / 9卷 / 05期

关键词：

ACTIVATED PROTEIN-KINASE; NEGATIVE BREAST-CANCER; FATTY-ACID SYNTHASE; PANCREATIC-CANCER; IN-VITRO; NEOADJUVANT CHEMOTHERAPY; DIABETIC-PATIENTS; MAMMALIAN TARGET; AMPK ACTIVATOR; CELL-GROWTH;

D O I：

10.1158/1535-7163.MCT-09-1186

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metformin is the most widely used antidiabetic drug in the world, and there is increasing evidence of a potential efficacy of this agent as an anticancer drug. First, epidemiological studies show a decrease in cancer incidence in metformin-treated patients. Second, metformin decreases insulin resistance and indirectly reduces insulin level, a beneficial effect because insulin promotes cancer cell growth. Third, several reports outline a direct inhibitory effect of metformin on cancer cell growth and an antitumoral action. Finally, metformin activates the AMP activated protein kinase (AMPK) pathway, a major sensor of the energetic status of the cell, which has been proposed as a promising therapeutic target in cancer. Mol Cancer Ther; 9(5); 1092-9. (C) 2010 AACR.

引用

页码：1092 / 1099

页数：8

共 69 条

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