Levels of Soluble CD14 and Tumor Necrosis Factor Receptors 1 and 2 May Be Predictive of Death in Severe Coronavirus Disease 2019

被引：31

作者：

Bowman, Emily R. ^{[1
]}

Cameron, Cheryl M. Ainslie ^{[2
]}

Avery, Ann ^{[3
,4
]}

Gabriel, Janelle ^{[1
]}

Kettelhut, Aaren ^{[1
]}

Hecker, Michelle ^{[3
,4
]}

Sontich, Claudia Ute ^{[3
]}

Tamilselvan, Banumathi ^{[2
]}

Nichols, Carmen N. ^{[5
]}

Richardson, Brian ^{[2
,5
]}

Cartwright, Michael ^{[5
]}

Funderburg, Nicholas T. ^{[1
]}

Cameron, Mark J. ^{[5
]}

机构：

[1] Ohio State Univ, Sch Hlth & Rehabil Sci, Div Med Lab Sci, Columbus, OH 43210 USA

[2] Case Western Reserve Univ, Dept Nutr, Cleveland, OH USA

[3] MetroHlth Med Ctr, Div Infect Dis, Cleveland, OH USA

[4] Case Western Reserve Univ, Sch Med, Cleveland, OH USA

[5] Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 223卷 / 05期

关键词：

SARS-CoV-2; monocytes; tumor necrosis factor; COVID-19; MORTALITY;

D O I：

10.1093/infdis/jiaa744

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

People infected with severe acute respiratory syndrome coronavirus 2 display a wide range of illness, from asymptomatic infection to severe respiratory distress resulting in death. We measured serum biomarkers in uninfected individuals and in individuals with mild, moderate, or critical coronavirus disease 2019 (COVID-19) disease. Levels of monocyte activation (soluble CD14 and fatty acid-binding protein 4) and inflammation (tumor necrosis factor receptors 1 and 2 [TNFR1 and TNFR2]) were increased in COVID-19 individuals, regardless of disease severity. Among patients with critical disease, individuals who recovered from COVID-19 had lower levels of TNFR1 and TNFR2 at hospital admission compared to these levels in patients with critical disease who ultimately died.

引用

页码：805 / 810

页数：6

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