HIV-1 subtypes in pregnant women in the UK

被引：1

作者：

Cortina-Borja, M.

Williams, D.

Cubitt, W. D.

Tookey, P. A.

Newell, M-L

Peckham, C. S.

机构：

[1] UCL, Inst Child Hlth, Ctr Paediat Epidemiol & Biostat, London WC1N 1EH, England

[2] Great Ormond St Hosp Sick Children, Dept Virol, London WC1N 3JH, England

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2007年 / 18卷 / 03期

关键词：

HIV-1; subtypes; serological assay; unlinked anonymous neonatal surveillance;

D O I：

10.1258/095646207780132352

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We analyse the distribution of HIV-1 subtypes in HIV-1-seropositive samples from 333,270 residual neonatal dried blood spot samples tested for routine newborn screening tests in the UK between July 1999 and December 2002. Of the 813 antibody-positive samples shown to contain passively acquired, maternal HIV-1 for which subtyping was attempted, 333 (41%) could not be subtyped due to cross-reactivity or low values of the assay results, and 480 (59%) were classified as B (35, 7.3%) or non-B (445, 92.7%). The proportions of subtyped B samples differed significantly (P = 0.004) between those from neonates whose mothers were born in the UK (21.4%) and those from neonates whose mothers were known to be born abroad (7%). Using a serological approach to establish viral serotype, we document the distribution of HIV-1 subtypes in infected pregnant women in the UK.

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页码：160 / 162

页数：3

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