Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

被引：757

作者：

Mackay, Laura K. ^{[1
,2
]}

Minnich, Martina ^{[3
]}

Kragten, Natasja A. M. ^{[4
]}

Liao, Yang ^{[5
,6
]}

Nota, Benjamin ^{[7
]}

Seillet, Cyril ^{[5
,6
]}

Zaid, Ali ^{[1
]}

Man, Kevin ^{[5
,6
]}

Preston, Simon ^{[5
,6
]}

Freestone, David ^{[1
]}

Braun, Asolina ^{[1
]}

Wynne-Jones, Erica ^{[1
]}

Behr, Felix M. ^{[4
,5
,6
,8
]}

Stark, Regina ^{[4
]}

Pellicci, Daniel G. ^{[1
,2
]}

Godfrey, Dale I. ^{[1
,2
]}

Belz, Gabrielle T. ^{[5
,6
]}

Pellegrini, Marc ^{[5
,6
]}

Gebhardt, Thomas ^{[1
]}

Busslinger, Meinrad ^{[3
]}

Shi, Wei ^{[5
,9
]}

Carbone, Francis R. ^{[1
]}

van Lier, Rene A. W. ^{[4
]}

Kallies, Axel ^{[5
,6
,7
]}

van Gisbergen, Klaas P. J. M. ^{[4
,5
,6
,7
,8
,9
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia

[2] Univ Melbourne, ARC, Ctr Excellence Adv Mol Imaging, Melbourne, Vic, Australia

[3] Vienna Bioctr VBC, Res Inst Mol Pathol IMP, Vienna, Austria

[4] Univ Amsterdam, Acad Med Ctr, Dept Hematopoiesis, Sanquin Res & Landsteiner Lab, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[5] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

[6] Univ Melbourne, Dept Med Biol, Melbourne, Vic, Australia

[7] Univ Amsterdam, AMC, Sanquin Res & Landsteiner Lab, Dept Blood Cell Res, Amsterdam, Netherlands

[8] AMC, Dept Expt Immunol, Amsterdam, Netherlands

[9] Univ Melbourne, Dept Comp & Informat Syst, Melbourne, Vic, Australia

来源：

SCIENCE | 2016年 / 352卷 / 6284期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会; 欧洲研究理事会;

关键词：

MEMORY T-CELLS; PERIPHERAL-TISSUES; DIFFERENTIATION; INFECTION; IMMUNITY; INNATE; SKIN; BET; PATHWAY; TRIGGER;

D O I：

10.1126/science.aad2035

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.

引用

页码：459 / 463

页数：5

共 30 条

[1] Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert [J].

Ariotti, Silvia ;

Hogenbirk, Marc A. ;

Dijkgraaf, Feline E. ;

Visser, Lindy L. ;

Hoekstra, Mirjam E. ;

Song, Ji-Ying ;

Jacobs, Heinz ;

Haanen, John B. ;

Schumacher, Ton N. .

SCIENCE, 2014, 346 (6205) :101-105

[2] Long-term retention of mature NK1.1+ NKT cells in the thymus [J].

Berzins, Stuart P. ;

McNab, Finlay W. ;

Jones, Claerwen M. ;

Smyth, Mark J. ;

Godfrey, Dale I. .

JOURNAL OF IMMUNOLOGY, 2006, 176 (07) :4059-4065

[3] Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans [J].

Braga, Felipe A. Vieira ;

Hertoghs, Kirsten M. L. ;

Kragten, Natasja A. M. ;

Doody, Gina M. ;

Barnes, Nicholas A. ;

Remmerswaal, Ester B. M. ;

Hsiao, Cheng-Chih ;

Moerland, Perry D. ;

Wouters, Diana ;

Derks, Ingrid A. M. ;

van Stijn, Amber ;

Demkes, Marc ;

Hamann, Jorg ;

Eldering, Eric ;

Nolte, Martijn A. ;

Tooze, Reuben M. ;

ten Berge, Ineke J. M. ;

van Gisbergen, Klaas P. J. M. ;

van Lier, Rene A. W. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2015, 45 (10) :2945-2958

[4] Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics [J].

Bromley, SK ;

Thomas, SY ;

Luster, AD .

NATURE IMMUNOLOGY, 2005, 6 (09) :895-901

[5] T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow [J].

Daussy, Cecile ;

Faure, Fabrice ;

Mayol, Katia ;

Viel, Sebastien ;

Gasteiger, Georg ;

Charrier, Emily ;

Bienvenu, Jacques ;

Henry, Thomas ;

Debien, Emilie ;

Hasan, Uzma A. ;

Marvel, Jacqueline ;

Yoh, Keigyou ;

Takahashi, Satoru ;

Prinz, Immo ;

de Bernard, Simon ;

Buffat, Laurent ;

Walzer, Thierry .

JOURNAL OF EXPERIMENTAL MEDICINE, 2014, 211 (03) :563-577

[6] Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues [J].

Debes, GF ;

Arnold, CN ;

Young, AJ ;

Krautwald, S ;

Lipp, M ;

Hay, JB ;

Butcher, EC .

NATURE IMMUNOLOGY, 2005, 6 (09) :889-894

[7] Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs [J].

Gasteiger, Georg ;

Fan, Xiying ;

Dikiy, Stanislav ;

Lee, Sue Y. ;

Rudensky, Alexander Y. .

SCIENCE, 2015, 350 (6263) :981-985

[8] Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells [J].

Gattinoni, Luca ;

Zhong, Xiao-Song ;

Palmer, Douglas C. ;

Ji, Yun ;

Hinrichs, Christian S. ;

Yu, Zhiya ;

Wrzesinski, Claudia ;

Boni, Andrea ;

Cassard, Lydie ;

Garvin, Lindsay M. ;

Paulos, Chrystal M. ;

Muranski, Pawel ;

Restifo, Nicholas P. .

NATURE MEDICINE, 2009, 15 (07) :808-U129

[9] Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus [J].

Gebhardt, Thomas ;

Wakim, Linda M. ;

Eidsmo, Liv ;

Reading, Patrick C. ;

Heath, William R. ;

Carbone, Francis R. .

NATURE IMMUNOLOGY, 2009, 10 (05) :524-530

[10] The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation [J].

Gordon, Scott M. ;

Chaix, Julie ;

Rupp, Levi J. ;

Wu, Junmin ;

Madera, Sharline ;

Sun, Joseph C. ;

Lindsten, Tullia ;

Reiner, Steven L. .

IMMUNITY, 2012, 36 (01) :55-67

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