EORTC Elderly Task Force experts' opinion for the treatment of colon cancer in older patients

被引:51
|
作者
Pallis, A. G. [1 ]
Papamichael, D. [2 ]
Audisio, R. [3 ]
Peeters, M. [4 ]
Folprecht, G. [5 ]
Lacombe, D. [1 ]
Van Cutsem, E. [6 ]
机构
[1] EORTC Elderly Task Force, EORTC Headquarters, B-1200 Brussels, Belgium
[2] BOC Oncol Ctr, Dpt Med Oncol, Nicosia, Cyprus
[3] Univ Liverpool, St Helens Hosp, St Helens WA9 3DA, England
[4] Ghent Univ Hosp, Digest Oncol Unit, Dpt HepatoGastroenterol, B-9000 Ghent, Belgium
[5] Univ Hosp Carl Gustav Carus, Dept Med 1, D-01307 Dresden, Germany
[6] Univ Hosp Gasthuisberg, Digest Oncol Unit, B-3000 Louvain, Belgium
关键词
Colon cancer; Older; Age; Expert's opinion; EORTC; METASTATIC COLORECTAL-CANCER; QUALITY-OF-LIFE; ADJUVANT CHEMOTHERAPY; CLINICAL-TRIALS; LIVER METASTASES; POOLED ANALYSIS; SURGICAL-TREATMENT; PHASE-III; 5-FLUOROURACIL-BASED CHEMOTHERAPY; PREOPERATIVE ASSESSMENT;
D O I
10.1016/j.ctrv.2009.10.008
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
As a result Of an increasing life expectancy, the incidence of colon cancer in the older population is rising. As a consequence oncologists and their older patients commonly face the dilemma of whether or not to give/receive treatment for colon cancer. However. the Paucity of large, well conducted prospective trials makes it difficult to provide evidence-based clinical recommendations for these patients. The Current evidence supports the safety and efficacy of treatment for colon cancer in fit older patients and demonstrates that treatment outcome can be similar to that of their younger Counterparts. However, it should be noted that these data are derived from retrospective studies which are likely to suffer from selection bias. Despite a growing body of data, further work is still needed to establish optimal strategies to care for this special Population and prospective specific trials for older colon cancer patients are clearly needed. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:83 / 90
页数:8
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