Chelate titrations of Ca2+ and Mg2+ using microfluidic paper-based analytical devices

被引:69
作者
Karita, Shingo [1 ]
Kaneta, Takashi [1 ]
机构
[1] Okayama Univ, Grad Sch Nat Sci & Technol, Dept Chem, Okayama 7008530, Japan
基金
日本学术振兴会;
关键词
Chelate titration; Microfluidic paper-based analytical device; Hardness; Calcium; Magnesium; Natural water; CHEMILUMINESCENCE IMMUNOASSAY; IMMUNODEVICE; LACTOFERRIN; NITRITE; ASSAY;
D O I
10.1016/j.aca.2016.04.019
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
We developed microfluidic paper-based analytical devices (mu PADs) for the chelate titrations of Ca2+ and Mg2+ in natural water. The mu PAD consisted of ten reaction zones and ten detection zones connected through narrow channels to a sample zone located at the center. Buffer solutions with a pH of 10 or 13 were applied to all surfaces of the channels and zones. Different amounts of ethylenediaminetetraacetic acid (EDTA) were added to the reaction zones and a consistent amount of a metal indicator (Eriochrome Black T or Calcon) was added to the detection zones. The total concentrations of Ca2+ and Mg2+ (total hardness) in the water were measured using a mu PAD containing a buffer solution with a pH of 10, whereas only Ca2+ was titrated using a mu PAD prepared with a potassium hydroxide solution with a pH of 13. The mu PADs permitted the determination of Ca2+ and Mg2+ in mineral water, river water, and seawater samples within only a few minutes using only the naked eye-no need of instruments. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:60 / 67
页数:8
相关论文
共 31 条
[1]  
[Anonymous], CHEM OCEANOGRAPHY
[2]  
[Anonymous], COMPREHENSIVE ANAL B
[3]  
[Anonymous], COMPREHENSIVE GLYCOS
[4]   Development of paper-based microfluidic analytical device for iron assay using photomask printed with 3D printer for fabrication of hydrophilic and hydrophobic zones on paper by photolithography [J].
Asano, Hitoshi ;
Shiraishi, Yukihide .
ANALYTICA CHIMICA ACTA, 2015, 883 :55-60
[5]   Two-ply channels for faster wicking in paper-based microfluidic devices [J].
Camplisson, Conor K. ;
Schilling, Kevin M. ;
Pedrotti, William L. ;
Stone, Howard A. ;
Martinez, Andres W. .
LAB ON A CHIP, 2015, 15 (23) :4461-4466
[6]   Understanding Wax Printing: A Simple Micropatterning Process for Paper-Based Microfluidics [J].
Carrilho, Emanuel ;
Martinez, Andres W. ;
Whitesides, George M. .
ANALYTICAL CHEMISTRY, 2009, 81 (16) :7091-7095
[7]   Recent Developments in Paper-Based Microfluidic Devices [J].
Cate, David M. ;
Adkins, Jaclyn A. ;
Mettakoonpitak, Jaruwan ;
Henry, Charles S. .
ANALYTICAL CHEMISTRY, 2015, 87 (01) :19-41
[8]   Simple, distance-based measurement for paper analytical devices [J].
Cate, David M. ;
Dungchai, Wijitar ;
Cunningham, Josephine C. ;
Volckens, John ;
Henry, Charles S. .
LAB ON A CHIP, 2013, 13 (12) :2397-2404
[9]   Paper-Based ELISA [J].
Cheng, Chao-Min ;
Martinez, Andres W. ;
Gong, Jinlong ;
Mace, Charles R. ;
Phillips, Scott T. ;
Carrilho, Emanuel ;
Mirica, Katherine A. ;
Whitesides, George M. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (28) :4771-4774
[10]   3D Origami-based multifunction-integrated immunodevice: low-cost and multiplexed sandwich chemiluminescence immunoassay on microfluidic paper-based analytical device [J].
Ge, Lei ;
Wang, Shoumei ;
Song, Xianrang ;
Ge, Shenguang ;
Yu, Jinghua .
LAB ON A CHIP, 2012, 12 (17) :3150-3158