Clinical blockade of PD1 and LAG3-potential mechanisms of action

被引：517

作者：

Nguyen, Linh T. ^{[1
]}

Ohashi, Pamela S. ^{[1
]}

机构：

[1] Princess Margaret Canc Ctr, Immune Therapy Program, Toronto, ON M5G 2M9, Canada

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 01期

关键词：

T-CELL-ACTIVATION; CHRONIC VIRAL-INFECTION; LYMPHOCYTE-ACTIVATION; PROGRAMMED DEATH-1; PHASE-I; ADVANCED MELANOMA; IMMUNE-RESPONSES; PD-1; EXPRESSION; B-CELLS; INHIBITORY RECEPTORS;

D O I：

10.1038/nri3790

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dysfunctional T cells can render the immune system unable to eliminate infections and cancer. Therapeutic targeting of the surface receptors that inhibit T cell function has begun to show remarkable success in clinical trials. In this Review, we discuss the potential mechanisms of action of the clinical agents that target two of these receptors, programmed cell death protein 1 (PD1) and lymphocyte activation gene 3 protein (LAG3). We also suggest correlative studies that may define the predominant mechanisms of action and identify predictive biomarkers.

引用

页码：45 / 56

页数：12

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