In vitro combination of voriconazole with micafungin against azole-resistant clinical isolates of Aspergillus fumigatus from different geographical regions

被引：8

作者：

Fakhim, Hamed ^{[1
,2
]}

Vaezi, Afsane ^{[3
,4
]}

Dannaoui, Eric ^{[5
]}

Sharma, Cheshta ^{[6
]}

Mousavi, Bita ^{[7
]}

Chowdhary, Anuradha ^{[6
]}

Meis, Jacques F. ^{[8
,9
]}

Badali, Hamid ^{[3
,10
]}

机构：

[1] Urmia Univ Med Sci, Dept Med Parasitol & Mycol, Fac Med, Orumiyeh, Iran

[2] Urmia Univ Med Sci, Cellular & Mol Res Ctr, Orumiyeh, Iran

[3] Mazandaran Univ Med Sci, Sch Med, Dept Med Mycol, Sari, Iran

[4] Mazandaran Univ Med Sci, Student Res Comm, Sari, Iran

[5] Univ Paris 05, Hop Europeen Georges Pompidou, AP HP, Fac Med,Unite Parasitol Mycol,Serv Microbiol, Paris, France

[6] Univ Delhi, Vallabhbhai Patel Chest Inst, Dept Med Mycol, Delhi, India

[7] Paris Est Creteil Univ, Dynamyc Res Grp EA 7380, Ecole Natl Vet Alfort, Creteil, France

[8] Canisius Wilhelmina Hosp CWZ, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands

[9] Ctr Expertise Mycol Radboudumc CWZ, Nijmegen, Netherlands

[10] Mazandaran Univ Med Sci, Hemoglobinopathy Inst, Pharmaceut Sci Res Ctr, Sari, Iran

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2018年 / 91卷 / 03期

关键词：

In vitro interactions; Voriconazole; Micafungin; Aspergillus fumigatus; INVASIVE ASPERGILLOSIS; ANTIFUNGAL THERAPY; AMPHOTERICIN-B; CASPOFUNGIN; ANIDULAFUNGIN; ITRACONAZOLE; PREVALENCE; MANAGEMENT; SYNERGY; SPP;

D O I：

10.1016/j.diagmicrobio.2018.03.003

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In vitro interaction of voriconazole with micafungin was evaluated against 33 clinical Aspergillus fumigatus isolates, including azole-resistant (n = 31) and -susceptible (n = 2) isolates. Interaction was synergistic for only I resistant isolate carrying the TR34/L98H mutation. No antagonistic effects were observed for 96.8% of azole-resistant isolates. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：266 / 268

页数：3

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