Alternative mRNA splicing in cancer immunotherapy

被引：202

作者：

Frankiw, Luke ^{[1
]}

Baltimore, David ^{[1
]}

Li, Guideng ^{[2
,3
]}

机构：

[1] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, Ctr Syst Med, Beijing, Peoples R China

[3] Suzhou Inst Syst Med, Suzhou, Peoples R China

来源：

NATURE REVIEWS IMMUNOLOGY | 2019年 / 19卷 / 11期

关键词：

CELL ANTIGEN DISCOVERY; DR-RESTRICTED EPITOPES; T-CELLS; SINGLE-CELL; ACQUIRED-RESISTANCE; INTRON RETENTION; TUMOR-ANTIGEN; MUTATIONAL LANDSCAPE; FUNCTIONAL IMPACT; CTLA-4; BLOCKADE;

D O I：

10.1038/s41577-019-0195-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunotherapies are yielding effective treatments for several previously untreatable cancers. Still, the identification of suitable antigens specific to the tumour that can be targets for cancer vaccines and T cell therapies is a challenge. Alternative processing of mRNA, a phenomenon that has been shown to alter the proteomic diversity of many cancers, may offer the potential of a broadened target space. Here, we discuss the promise of analysing mRNA processing events in cancer cells, with an emphasis on mRNA splicing, for the identification of potential new targets for cancer immunotherapy. Further, we highlight the challenges that must be overcome for this new avenue to have clinical applicability.

引用

页码：675 / 687

页数：13

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