Signaling by Gasotransmitters

被引：689

作者：

Mustafa, Asif K. ^{[1
]}

Gadalla, Moataz M. ^{[2
]}

Snyder, Solomon H. ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

来源：

SCIENCE SIGNALING | 2009年 / 2卷 / 68期

关键词：

NITRIC-OXIDE SYNTHASE; PROTEIN S-NITROSYLATION; CARBON-MONOXIDE; HYDROGEN-SULFIDE; HEME OXYGENASE-2; CELL-DEATH; SENSITIVE FACTOR; RELAXING FACTOR; SMOOTH-MUSCLE; NO-SYNTHASE;

D O I：

10.1126/scisignal.268re2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide is well established as a major signaling molecule. Evidence is accumulating that carbon monoxide and hydrogen sulfide also are physiologic mediators in the cardiovascular, immune, and nervous systems. This Review focuses on mechanisms whereby they signal by binding to metal centers in metalloproteins, such as in guanylyl cyclase, or modifying sulfhydryl groups in protein targets.

引用

页数：8

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