Cross-sectional prevalence of SARS-CoV-2 antibodies in healthcare workers in paediatric facilities in eight

被引：25

作者：

Goldblatt, D. ^{[1
,2
]}

Johnson, M. ^{[1
]}

Falup-Pecurariu, O. ^{[3
]}

Ivaskeviciene, I. ^{[4
]}

Spoulou, V ^{[5
]}

Tamm, E. ^{[6
]}

Wagner, M. ^{[7
]}

Zar, H. J. ^{[9
,10
]}

Bleotu, L. ^{[3
]}

Ivaskevicius, R. ^{[4
]}

Papadatou, I ^{[11
]}

Jogi, P. ^{[6
]}

Lischka, J. ^{[8
]}

Franckling-Smith, Z. ^{[9
,10
]}

Isarova, D. ^{[12
]}

Grandjean, L. ^{[1
,2
]}

Zavadska, D. ^{[12
]}

机构：

[1] UCL, Great Ormond St Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England

[2] Great Ormond St Childrens Hosp NHS Fdn Trust, London, England

[3] Transilvania Univ, Childrens Clin Hosp, Fac Med, Brasov, Romania

[4] Vilnius Univ, Paediat Ctr, Inst Clin Med, Vilnius, Lithuania

[5] Agia Sophia Childrens Hosp Athens, Athens, Greece

[6] Tartu Univ Hosp, Childrens Clin, Tartu, Estonia

[7] Med Univ Vienna, Comprehens Ctr Paediat, Dept Paediat, Div Neonatol Paediat Intens Care & Neuropaediat, Vienna, Austria

[8] Med Univ Vienna, Clin Div Paediat Pulmonol Allergol & Endocrinol, Dept Paediat & Adolescent Med, Comprehens Ctr Paediat, Vienna, Austria

[9] Univ Cape Town, Dept Paediat & Child Hlth, Cross Childrens Hosp, Cape Town, South Africa

[10] Univ Cape Town, SA MRC Unit Child & Adolescent Hlth, Cape Town, South Africa

[11] Natl & Kapodistrian Univ Athens, Immunobiol & Vaccinol Res Lab, Athens, Greece

[12] Childrens Clin Univ Hosp, Riga, Latvia

来源：

JOURNAL OF HOSPITAL INFECTION | 2021年 / 110卷

基金：

英国医学研究理事会;

关键词：

COVID-19; SARS-CoV-2; Seroprevalence; Healthcare workers; Hospital workers; SEROPREVALENCE;

D O I：

10.1016/j.jhin.2020.12.019

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Healthcare workers (HCWs) have been disproportionately affected by coronavirus disease 2019 (COVID-19), which may be driven, in part, by nosocomial exposure. If HCW exposure is predominantly nosocomial, HCWs in paediatric facilities, where few patients are admitted with COVID-19, may lack antibodies to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and be at increased risk during the current resurgence. Aim: To compare the seroprevalence of SARS-CoV-2 amongst HCWs in paediatric facilities in seven European countries and South Africa (N1/48). Methods: All categories of paediatric HCWs were invited to participate in the study, irrespective of previous symptoms. A single blood sample was taken and data about previous symptoms were documented. Serum was shipped to a central laboratory in London where SARS-CoV-2 immunoglobulin G was measured. Findings: In total, 4114 HCWs were recruited between 1st May and mid-July 2020. The range of seroprevalence was 0-16.93%. The highest seroprevalence was found in London (16.93%), followed by Cape Town, South Africa (10.36%). There were no positive HCWs in the Austrian, Estonian and Latvian cohorts; 2/300 [0.66%, 95% confidence interval (CI) 0.18-2.4] HCWs tested positive in Lithuania; 1/124 (0.81%, 95% CI 0.14-4.3) HCWs tested positive in Romania; and 1/76 (1.3%, 95% CI 0.23-7.0) HCWs tested positive in Greece. Conclusion: Overall seroprevalence amongst paediatric HCWs is similar to their national populations and linked to the national COVID-19 burden. Staff working in paediatric facilities in low-burden countries have very low seroprevalence rates and thus are likely to be susceptible to COVID-19. Their susceptibility to infection may affect their ability to provide care in the face of increasing cases of COVID-19, and this highlights the need for appropriate preventative strategies in paediatric healthcare settings. (C) 2021 The Author(s). Published by Elsevier Ltd on behalf of The Healthcare Infection Society.

引用

页码：60 / 66

页数：7

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