Synthesis and application of hydroxyapatite/polylactide composite biomaterial

被引：75

作者：

Ignjatovic, N ^{[1
]}

Uskokovic, D ^{[1
]}

机构：

[1] Acad Sci & Arts, Inst Tech Sci, YU-11000 Belgrade, Serbia Monteneg, Serbia

来源：

APPLIED SURFACE SCIENCE | 2004年 / 238卷 / 1-4期

关键词：

hydroxyapatite/poly-L-lactide; structure designing; hot pressing; mechanical properties; Ii vitro and in vivo research;

D O I：

10.1016/j.apsusc.2004.05.227

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Hydroxyapatite/bioresorbable-polymer composite biomaterials can be used for the bone tissue reconstruction. There are different methods to obtain hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterial, but up to now only hot pressing and forging have been successfully used to produce blocks with mechanical properties similar to the natural bone tissue. By dissolving PLLA polymer mixed with HAp, highly porous HAp/PLLA composite biomaterial was obtained. A wide spectrum of blocks with different properties was produced by hot pressing, varying the pressing parameters. HAp/PLLA blocks were implanted into mice (intraperitoneally) and after implantation, the phenomenon was studied histopathologically and by FT-IR spectroscopy. The obtained composite biomaterial blocks have a compressive strength of up to 140 MPa and elasticity module of up to 10 GPa. After implantation, good adhesion of the surrounding tissue on the surface of the implant as well as its integration indicate high degree of its biocompatibility. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：314 / 319

页数：6

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