Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain

被引：242
作者：
Gibbins, JM
Okuma, M
Farndale, R
Barnes, M
Watson, SP
机构：
[1] STRANGEWAYS RES LAB,CAMBRIDGE CB1 4RN,ENGLAND
[2] UNIV CAMBRIDGE,DEPT BIOCHEM,CAMBRIDGE CB2 1QW,ENGLAND
[3] KYOTO UNIV,GRAD SCH MED,DEPT HEMATOL & ONCOL,SAKYO KU,KYOTO 60601,JAPAN
来源：
FEBS LETTERS | 1997年 / 413卷 / 02期
基金：
英国惠康基金;
关键词：
collagen receptor; human platelet; glycoprotein VI; Fc receptor gamma-chain;
D O I：
10.1016/S0014-5793(97)00926-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have recently shown that collagen activates platelets through a pathway dependent on the Fc receptor gamma-chain and the tyrosine kinase Syk, We report here that the Fc receptor gamma-chain and the candidate collagen receptor glycoprotein VI (GPVI) co-associate, Furthermore, cross-linking GPVI stimulates a similar pattern of tyrosine phosphorylation to that stimulated by collagen, including tyrosine phosphorylation of Fc receptor gamma-chain, These results support a model where GPVI couples collagen-stimulation of platelets to phosphorylation of the Pc receptor gamma-chain leading to activation of Syk and phospholipase C gamma 2. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码：255 / 259
页数：5
相关论文
共 25 条
[1]   PLATELETS WITH 10-PERCENT OF THE NORMAL AMOUNT OF GLYCOPROTEIN-VI HAVE AN IMPAIRED RESPONSE TO COLLAGEN THAT RESULTS IN A MILD BLEEDING TENDENCY [J].
ARAI, M ;
YAMAMOTO, N ;
MOROI, M ;
AKAMATSU, N ;
FUKUTAKE, K ;
TANOUE, K .
BRITISH JOURNAL OF HAEMATOLOGY, 1995, 89 (01) :124-130
[2]   COLLAGEN STIMULATES TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE C-GAMMA-2 BUT NOT PHOSPHOLIPASE C-GAMMA-1 IN HUMAN PLATELETS [J].
BLAKE, RA ;
SCHIEVEN, GL ;
WATSON, SP .
FEBS LETTERS, 1994, 353 (02) :212-216
[3]  
CHIANG TM, 1982, J BIOL CHEM, V257, P7581
[4]   EVIDENCE FOR A ROLE FOR TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE C-GAMMA-2 IN COLLAGEN-INDUCED PLATELET CYTOSOLIC CALCIUM MOBILIZATION [J].
DANIEL, JL ;
DANGELMAIER, C ;
SMITH, JB .
BIOCHEMICAL JOURNAL, 1994, 302 :617-622
[5]   DISTURBED PLATELET-AGGREGATION TO COLLAGEN ASSOCIATED WITH AN ANTIBODY AGAINST AN 85-KD TO 90-KD PLATELET GLYCOPROTEIN IN A PATIENT WITH PROLONGED BLEEDING-TIME [J].
DECKMYN, H ;
VANHOUTTE, E ;
VERMYLEN, J .
BLOOD, 1992, 79 (06) :1466-1471
[6]  
DUCHEMIN AM, 1994, J BIOL CHEM, V269, P12111
[7]   Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets [J].
Gibbins, J ;
Asselin, J ;
Farndale, R ;
Barnes, M ;
Law, CL ;
Watson, SP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (30) :18095-18099
[8]  
GREENBERG S, 1994, J BIOL CHEM, V269, P3897
[9]  
Ichinohe T, 1997, J BIOL CHEM, V272, P63
[10]  
ICHINOHE T, 1995, J BIOL CHEM, V270, P28029
123