Pathophysiology of Autoimmune Bullous Diseases: Nature Versus Nurture

被引：16

作者：

Patel, Forum ^{[1
]}

Wilken, Reason ^{[1
]}

Patel, Falin B. ^{[1
]}

Sultani, Hawa ^{[1
]}

Bustos, Itzel ^{[1
]}

Duong, Christopher ^{[1
]}

Zone, John J. ^{[2
]}

Raychaudhuri, Siba P. ^{[3
,4
]}

Maverakis, Emanual ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Dermatol, Sacramento, CA 95816 USA

[2] Univ Utah, Dept Dermatol, Salt Lake City, UT USA

[3] VA Northern Calif Med Ctr, Dept Rheumatol, Mather, CA USA

[4] Univ Calif Davis, Sch Med, Div Rheumatol Allergy & Clin Immunol, Sacramento, CA 95816 USA

来源：

INDIAN JOURNAL OF DERMATOLOGY | 2017年 / 62卷 / 03期

关键词：

Autoimmune blistering diseases; desmoglein; pemphigoid; pemphigus; PEMPHIGUS-VULGARIS; FACTORS FACTS; HUMAN SKIN; ACANTHOLYSIS; PATHOGENESIS; DISORDERS; INDUCTION; DIAGNOSIS; FOLIACEUS; LESIONS;

D O I：

10.4103/0019-5154.159620

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Pemphigus and pemphigoid are the prototypical immunobullous diseases. Although it has been well established that they are caused by deposition of autoreactive antibodies directed against adherence proteins within the skin, the specific genetic and environmental factors leading to development of these diseases continue to be an area of investigation. Herein, we discuss several of the potential environmental triggers that may induce patients to develop immunobullous diseases including medications, viral infections, UV exposure or other radiation injury and dietary factors. In addition, the potential genetic and immunologic mechanisms contributing to the pathogenesis of pemphigus and pemphigoid will be reviewed. The multifactorial nature of these diseases contributes to their complexity and highlights the importance of a detailed personal and family history when caring for these patients.

引用

页码：262 / 267

页数：6

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